medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2020-99-10-1120-1126medlit-1074Research ArticleМЕДИЦИНА ТРУДАOCCUPATIONAL HEALTHРоль молекул межклеточной адгезии и антител к окисленным липопротеидам низкой плотности в патогенезе сердечно-сосудистых заболеваний при воздействии ртутиRole of intercellular adhesion molecules and antibodies to oxidized LDL in pathogenesis of cardiovascular diseases under mercury exposurehttps://orcid.org/0000-0002-5353-2268НаумоваОльга ВячеславовнаNaumovaOlga V.

Мл. науч. сотр. лаб. иммуно-биохимических и молекулярно-генетических исследований в гигиене ФГБНУ ВСИМЭИ, 665827, Ангарск.

e-mail: Naumova-Olga-V@mail.ru

MD, junior research associate. immuno-biochemical and molecular genetic research in hygiene. East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.

e-mail: Naumova-Olga-V@mail.ru

naumova-olga-v@mail.ruhttps://orcid.org/0000-0002-5608-0818КудаеваИ. В.KudaevaIrina V.noemail@neicon.ruhttps://orcid.org/0000-0002-1400-6345МаснавиеваЛ. Б.MasnavievaLyudmila B.noemail@neicon.ruhttps://orcid.org/0000-0002-4903-1401ДьяковичО. А.DyakovichOlga A.noemail@neicon.ruФГБНУ «Восточно-Сибирский институт медико-экологических исследований»East-Siberian Institute of Medical and Ecological Research202001122020991011201126Copyright © Наумова О.В., Кудаева И.В., Маснавиева Л.Б., Дьякович О.А., 20202020Наумова О.В., Кудаева И.В., Маснавиева Л.Б., Дьякович О.А.Naumova O.V., Kudaeva I.V., Masnavieva L.B., Dyakovich O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/1074Введение

Введение. Воздействие ртути и её соединений может являться фактором риска для развития сердечно-сосудистых заболеваний.

Цель - изучение уровня антител к окисленным липопротеидам низкой плотности (ЛПНП), молекул межклеточной адгезии - sICAM-1 и sVCAM-1 и фактора роста эндотелия сосудов VEGF у лиц, экспонированных ртутью.

Материал и методы

Материал и методы. Проведено поперечное обследование с применением биохимических методов у лиц, контактирующих в профессиональной деятельности с металлической ртутью со стажем работы более пяти лет, лиц с впервые установленным диагнозом хронической ртутной интоксикации и пациентов с хронической ртутной интоксикацией в отдалённом постконтактном периоде.

Результаты

Результаты. У лиц, экспонированных ртутью, имеющих в качестве сопутствующих сердечно-сосудистые заболевания, уровень sVCAM-1 различался в зависимости от наличия/отсутствия интоксикации и приобретал максимальные значения в её отдалённом периоде, а концентрации sICAM-1 и антител к окисленным ЛПНП значимо не различались. В группах без сердечно-сосудистой патологии в анамнезе, экспонированных ртутью, концентрация sVCAM-1 у пациентов с интоксикацией превышала, а sICAM-1 была ниже в 1,5-2 раза таковой у стажированных лиц, уровень антител к окисленным ЛПНП был максимальным при наличии интоксикации в её начальном периоде.

Заключение

Заключение. Роль антител к окисленным ЛПНП, молекул межклеточной адгезии заключается в их разнонаправленном участии в механизмах, сдерживающих или способствующих формированию сердечно-сосудистой патологии у лиц, экспонированных ртутью.

Introduction

Introduction. Exposure to mercury and its compounds can be a risk factor for the development of cardiovascular diseases.

The aim of the study is to investigate the levels of antibodies to oxidized LDL, intercellular adhesion molecules sICAM-1, sVCAM-1, and VEGF in individuals exposed to mercury.

Material and Methods

Material and Methods. A cross-sectional examination was carried out using biochemical methods in persons who have come into contact with metallic mercury with a work experience of more than five years, persons with a first established diagnosis of chronic mercury intoxication, and patients with chronic mercury intoxication in the long-term postexposure period.

Results

Results. In persons exposed to mercury with concomitant cardiovascular diseases, the level of sVCAM-1 differed depending on the presence/absence of intoxication and acquired maximum values in its long-term period, while the concentrations of sICAM-1 and antibodies to oxidized LDL did not differ significantly. In the groups without cardiovascular pathology exposed to mercury, the concentration of sVCAM-1 was higher in patients with intoxication, and sICAM-1 was 1.5-2 times lower when compared with experienced individuals, the level of antibodies to oxidized LDL was maximum in the presence of intoxication in its initial period.

Discussion

Discussion. The progression of chronic mercury intoxication is accompanied by an increase in the level of sVCAM-1, and a gradual decrease in the content of sICAM-1 to reference values. Trained workers were found to have elevated sICAM-1 levels.

Conclusion

Conclusion. The role of antibodies to oxidized LDL, intercellular adhesion molecules is their multidirectional participation in the mechanisms that inhibit or contribute to the formation of cardiovascular pathology in individuals exposed to mercury.

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The authors declare that there are no conflicts of interest present.