medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2020-99-12-1365-1369medlit-1134Research ArticleГИГИЕНА ОКРУЖАЮЩЕЙ СРЕДЫENVIRONMENTAL HYGIENEКомплексообразующая способность органических соединений и их влияние на организм человека (обзор)Complexing ability of organic compounds and their influence on the human body (review)https://orcid.org/0000-0002-4632-6060ХлыстовИван АндреевичHlystovIvan A.

Канд. биол. наук, науч. сотр., ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург.

e-mail: hlistovia@ymrc.ru

Researcher (Non-Academic) - Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federation.

e-mail: hlistovia@ymrc.ru

hlistovia@ymrc.ruhttps://orcid.org/0000-0002-8846-8016ШтинТ. Н.ShtinTat’yana N.noemail@neicon.ruhttps://orcid.org/0000-0002-6475-7753ГурвичВ. Б.GurvichVladimir B.noemail@neicon.ruhttps://orcid.org/0000-0002-0723-8674КузьминаЕ. А.Kuz´minaElena A.noemail@neicon.ruhttps://orcid.org/0000-0002-6562-2842БугаеваА. В.BugayevaAleksandra V.noemail@neicon.ruhttps://orcid.org/0000-0001-7927-0246ХарьковаП. К.Khar´kovaPolina K.noemail@neicon.ruФБУН «Екатеринбургский медицинский - научный центр профилактики и охраны здоровья рабочих промпредприятий» РоспотребнадзораYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial WorkersФБУЗ «Федеральный центр гигиены и эпидемиологии» РоспотребнадзораCenter for Hygiene and Epidemiology202020012021991213651369Copyright © Хлыстов И.А., Штин Т.Н., Гурвич В.Б., Кузьмина Е.А., Бугаева А.В., Харькова П.К., 20212021Хлыстов И.А., Штин Т.Н., Гурвич В.Б., Кузьмина Е.А., Бугаева А.В., Харькова П.К.Hlystov I.A., Shtin T.N., Gurvich V.B., Kuz´mina E.A., Bugayeva A.V., Khar´kova P.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/1134

Введение. Существует острая проблема увеличения содержания органических веществ в природных водах, расширения перечня поступающих веществ в водоёмы в связи с промышленной, хозяйственной деятельностью человека, изменениями климата. В этих условиях вероятно появление соединений с неизученными химическими и токсическими свойствами.

Цель работы – на основании имеющихся литературных данных собрать сведения о путях поступления органических соединений в водоёмы и организм человека, изучить данные о механизмах взаимодействия органических веществ с металлами, показать судьбу известных органических хелаторов, комплексообразователей и сформированных ими металлоорганических соединений внутри организма. Поиск литературы осуществлён по базам данных Scopus, Web of Science, CyberLeninka.

Источники поступления органических веществ в водоёмы, свойства органических веществ. Выделяют три группы органических веществ в водоёмах, разделяемых по источникам их появления (поступления): терригенного происхождения, образующиеся внутри водоёмов и поступающие из техногенных источников. Органические соединения способны образовывать растворимые и нерастворимые соединения с металлами и коллоидами.

Механизмы взаимодействия органических веществ с металлами. Образование связей органических веществ происходит по типу хелатирования и комплексообразования, зависит от наличия функциональных групп, молекулярной массы веществ, радиуса ионов, конкурирующих взаимодействий с сайтами связывания. К веществам, проявляющим связывающие свойства, относят фенольные соединения, карбоновые кислоты, полисахариды, флавоноиды. В связи с тем, что фенольные соединения в больших количествах содержатся в растительной и животной ткани, данная группа соединений с позиции взаимодействий с металлами и токсикометрии изучена более подробно.

Поступление органических и органометаллических соединений в организм, их кинетика, метаболизм и распад. Органические соединения, хелаты и комплексы поступают в организм с питьевой водой, продуктами и лекарствами, а также образуются в организме, в том числе путём замещения ионов. Представлена информация по биохимическим и токсикологическим исследованиям известных на сегодняшний день соединений.

Introduction. Increased content of organic substances in natural waters, expanding the list of input substances to water bodies, owing to industrial and economic activities of a person, and climate changes is an urgent issue. Against this background, compounds with unknown chemical and toxic properties are likely to appear.

The purpose of this study is to collect data concerning the ways for organic compounds entering water bodies and the human body, study data on interaction mechanisms of organic substances with metals, reveal the fate of known organic chelators, complexing agents as well as organometallic compound shaped by them inside the body. The literature search was carried out in Scopus, Web of Science, CyberLeninka databases.

Sources of organic substances entering water bodies, properties of organic substances. There are three types of organic substances in water bodies, divided by the sources of their occurrence (inflow): terrigenous origin, shaped inside water bodies and coming from man-made sources. Organic compounds may produce soluble and insoluble compounds with metals and colloids.

Mechanisms of interaction of organic substances with metals. Bonding of organic substances takes place by the type of chelation and complexation. There are factors for bonding: functional group content, the molecular mass of substances, ion radius, and competitive interaction with binding sites. Substances having binding properties include phenolic compounds, carboxylic acids, polysaccharides, and flavonoids. Considering that phenolic compounds are located in large quantities in plant and animal tissues, this group of compounds has been researched more thoroughly in terms of interactions with metals and toxicometry.

Intake of organic and organometallic compounds into the body, their kinetics, metabolism and decay. Organic compounds, chelates, and complexes enter the body with drinking water, food, and drugs. They are also generated in the body, including by replacing ions. Data on biochemical and toxicological studies of currently known compounds is given.

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