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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2021-100-9-1009-1012</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-1732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ ГИГИЕНИЧЕСКИХ ИССЛЕДОВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF HYGIENIC AND EXPERIMENTAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Гигиеническое и химико-аналитическое обеспечение безопасного применения пестицидов группы дитиокарбаматов</article-title><trans-title-group xml:lang="en"><trans-title>Hygienic and chemical-analytical support for the safe use of pesticides of the dithiocarbamate group</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8570-9769</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларькина</surname><given-names>Мария Вадимовна</given-names></name><name name-style="western" xml:lang="en"><surname>Larkina</surname><given-names>Maria V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. биол. наук, ст. науч. сотр. ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи.</p><p>e-mail: analyt1@yandex.ru</p></bio><bio xml:lang="en"><p>MD, PhD, Senior researcher, Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Mytishchi, 141014, Russian Federation.</p><p>e-mail: analyt1@yandex.ru</p></bio><email xlink:type="simple">analyt1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9633-5686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михеева</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikheeva</surname><given-names>Elena N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8860-5298</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>Svetlana G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1482-6319</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондарева</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondareva</surname><given-names>Lidiya G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр гигиены имени Ф.Ф. Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека</institution></aff><aff xml:lang="en"><institution>Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>06</day><month>09</month><year>2021</year></pub-date><volume>100</volume><issue>9</issue><fpage>1009</fpage><lpage>1012</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ларькина М.В., Михеева Е.Н., Федорова С.Г., Бондарева Л.Г., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ларькина М.В., Михеева Е.Н., Федорова С.Г., Бондарева Л.Г.</copyright-holder><copyright-holder xml:lang="en">Larkina M.V., Mikheeva E.N., Fedorova S.G., Bondareva L.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/1732">https://www.rjhas.ru/jour/article/view/1732</self-uri><abstract><sec><title>Введение</title><p>Введение. Существует тенденция увеличения использования новых химических веществ, большинство из которых являются потенциальными источниками риска для здоровья человека. Всё более актуальным является гигиеническая оценка их применения в регионах Российской Федерации при использовании различных технологий.</p><p>Цель работы — определение экспозиционных уровней манкоцеба, тирама и метирама (пестицидов группы дитиакарбаматов), установление порога допустимого риска воздействия пестицидов на рабочих при соблюдении технических рекомендаций и требований безопасности.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Для количественного определения манкоцеба, тирама и метирама использован метод газожидкостной хроматографии с пламенно-фотометрическим детектором; оценку риска проводили по экспозиции (КБсумм) и поглощённой дозе (КБп) при комплексном поступлении действующих веществ в организм работающих в соответствии с Методическими указаниями МУ 1.2.3017-12.</p></sec><sec><title>Результаты</title><p>Результаты. В результате анализа более 350 проб воздушной среды в рабочей зоне и смывов с открытых поверхностей кожи работающих установлено отсутствие в них действующих веществ манкоцеба и метирама и незначительное содержание тирама на уровне, близком к пределу его количественного определения.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты позволяют оценить риск безопасного применения препаратов на основе дитиокарбаматов в сельском хозяйств в рекомендуемых технологических режимах обработки, что является основой при прогнозировании общего химического воздействия на человека, точной оценки уровней загрязняющих веществ.</p></sec><sec><title>Участие авторов</title><p>Участие авторов: </p></sec><sec><title>Ларькина М</title><p>Ларькина М.В., Михеева Е.Н. — сбор и обработка материала;</p></sec><sec><title>Ларькина М</title><p>Ларькина М.В., Михеева Е.Н., Бондарева Л.Г. — написание текста, редактирование;</p></sec><sec><title>Ларькина М</title><p>Ларькина М.В., Федорова С.Г. — концепция и дизайн исследования.</p><p>Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикации данной статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело спонсорской поддержки.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. There is continued trend in recent years of increasing the use of new chemicals, most of which are potential sources of risk to human health. The hygienic assessment of their application in the regions of the Russian Federation using various technologies is becoming more and more relevant. </p><p>The aim of the work was to determine the exposure levels of mankoceb, tiram and metiram (pesticides of the dithiacarbamate group), to establish the threshold of the acceptable risk of exposure to pesticides for workers while complying with technical recommendations and safety requirements.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The determinations of the mancozeb, thiram and metiram were carried out by the gas-liquid chromatography with a flame-photometric detector (GC, FPD); the risk assessment was carried out by exposure (KBsumm) and absorbed dose (KBp) with a complex intake of active ingredients into the body of workers, under the Methodological Instructions № 1.2.3017-12.</p></sec><sec><title>Results</title><p>Results. There were analyzed more than 350 samples of air of the working zone and washing from workers’ skin. There was shown an absence of active substances mancozeb and metiram in them. The insignificant content of thiram at a level close to the limit of its quantitative determination was found.</p></sec><sec><title>Conclusion</title><p>Conclusion. The results obtained allow assessing the risk of safe use of drugs based on dithiocarbamates in agriculture, which is the basis for predicting the total chemical exposure to humans, and accurately evaluating the levels of pollutants.</p></sec><sec><title>Contributions</title><p>Contributions: </p></sec><sec><title>Larkina M</title><p>Larkina M.V. — collection and processing of the material, writing the text, editing, concept and design of the study;</p></sec><sec><title>Mikheeva E</title><p>Mikheeva E.N. — collection and processing of the material, writing the text, editing;</p></sec><sec><title>Fedorova S</title><p>Fedorova S.G. — concept and design of the study;</p></sec><sec><title>Bondareva L</title><p>Bondareva L.G. — writing the text, editing.</p><p>All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Acknowledgement</title><p>Acknowledgement. The study had no sponsorship.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дитиокарбаматы</kwd><kwd>операторы</kwd><kwd>аналитический контроль</kwd><kwd>оценка риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dithiocarbamates</kwd><kwd>operators</kwd><kwd>analytical control</kwd><kwd>risk assessment</kwd><kwd>health</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification. Available at: https://www.who.int/ipcs/publications/pesticides_hazard_2009.pdf</mixed-citation><mixed-citation xml:lang="en">WHO. The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification. 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