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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2022-101-3-331-337</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-2095</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИГИЕНА ДЕТЕЙ И ПОДРОСТКОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HYGIENE OF CHILDREN AND ADOLESCENTS</subject></subj-group></article-categories><title-group><article-title>Вклад переноса выбросов промышленных предприятий преобладающими ветрами в изменения медико-биологических показателей состояния здоровья населения</article-title><trans-title-group xml:lang="en"><trans-title>Contribution of the transfer of industrial emissions by predominate winds to changes in laboratory indicators of the state of population health</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0170-3085</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хрипач</surname><given-names>Людмила Васильевна</given-names></name><name name-style="western" xml:lang="en"><surname>Khripach</surname><given-names>Ludmila V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор биол. наук, вед. науч. сотр. отд. профилактической токсикологии и медико-биологических исследований ФГБУ «ЦСП» ФМБА России.</p><p>e-mail: LKhripach@cspmz.ru</p></bio><bio xml:lang="en"><p>MD, PhD, DSci., leading reseacher of the Department of Preventive Toxicology and Biomedical Research, Centre for Strategic Planning and Management of Biomedical Health Risks” of the Federal Medical Biological Agency, Moscow, 119121, Russian Federation.</p><p>e-mail: LKhripach@cspmz.ru</p></bio><email xlink:type="simple">lkhripach@cspmz.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4319-7192</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бударина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budarina</surname><given-names>Olga V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9339-9310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Железняк</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zheleznyak</surname><given-names>Evgeniya V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5279-5018</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Князева</surname><given-names>Т. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Knyazeva</surname><given-names>Tatiana D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4652-1755</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маковецкая</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Makovetskaya</surname><given-names>Anna K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4622-8110</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коганова</surname><given-names>З. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Koganova</surname><given-names>Zoya I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3505-8344</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сабирова</surname><given-names>З. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Sabirova</surname><given-names>Zulfiya F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8409-6713</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шипулина</surname><given-names>З. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shipulina</surname><given-names>Zinaida V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» Федерального медико-биологического агентства России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>04</month><year>2022</year></pub-date><volume>101</volume><issue>3</issue><fpage>331</fpage><lpage>337</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хрипач Л.В., Бударина О.В., Железняк Е.В., Князева Т.Д., Маковецкая А.К., Коганова З.И., Сабирова З.Ф., Шипулина З.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Хрипач Л.В., Бударина О.В., Железняк Е.В., Князева Т.Д., Маковецкая А.К., Коганова З.И., Сабирова З.Ф., Шипулина З.В.</copyright-holder><copyright-holder xml:lang="en">Khripach L.V., Budarina O.V., Zheleznyak E.V., Knyazeva T.D., Makovetskaya A.K., Koganova Z.I., Sabirova Z.F., Shipulina Z.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/2095">https://www.rjhas.ru/jour/article/view/2095</self-uri><abstract><sec><title>Введение</title><p>Введение. Горизонтальный перенос воздушных масс ветром играет большую роль в рассеивании промышленных выбросов от их первичных источников.</p><p>Цель исследования — оценка вклада повторяемости и силы преобладающих ветров в изменения медико-биологических показателей состояния организма детей дошкольного возраста, проживающих в небольшом городе на разных расстояниях и в разных направлениях от комплекса предприятий по переработке сельскохозяйственной продукции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В пробах слюны 112 детей 5–7 лет, посещающих детские сады, расположенные на расстоянии от 1,74 до 5,74 км от источника выбросов (ИВ) по направлению к юго-юго-западу (ЮЮЗ), юго-юго-востоку (ЮЮВ) и юго-востоку (ЮВ) от него, определяли интенсивность люминол-зависимой хемилюминесценции (ЛЗХЛ), содержание мочевой кислоты, секреторного IgA, ИЛ-1β, ИЛ-6 и ИЛ-8, активность α-амилазы и N-ацетил-β-D-глюкозаминидазы. По данным базы Meteoblue с усреднением за год проведения обследования рассчитаны интегральные показатели повторяемости ветров разной скорости, дующих в сторону города с северо-северо-востока (ССВ), северо-северо-запада (ССЗ) и северо-запада (СЗ) (W, км/год).</p></sec><sec><title>Результаты</title><p>Результаты. В качестве маркёра эффекта выбрана интенсивность ЛЗХЛ слюны детей как имевшая наиболее выраженную связь с расстояниями до ИВ (R = –0,524; p = 7 • 10–9). С помощью двухфакторного регрессионного анализа показано, что расстояние между детскими садами и ИВ определяет 49% общей дисперсии этого маркера с величиной р = 3 • 10–8, а перенос выбросов с преобладающими ветрами обусловливает 16% общей дисперсии с величиной р = 0,058. Полученная трёхмерная модель объясняет причину достоверных различий маркера между детьми из двух равноудалённых от ИВ детских садов с двукратным различием в переносе выбросов ветром.</p></sec><sec><title>Ограничения исследования</title><p>Ограничения исследования. Для разработки трёхмерной модели использовали архивные данные при теоретической возможности планирования обследования населения с более полным охватом румбов розы ветров.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты свидетельствуют о перспективности оценки вклада преобладающих ветров при анализе данных гигиенических обследований населения в районах расположения промышленных предприятий.</p></sec><sec><title>Участие авторов</title><p>Участие авторов: </p></sec><sec><title>Хрипач Л</title><p>Хрипач Л.В. — концепция и дизайн исследования, анализ повторяемости ветров, математическая обработка результатов, написание текста;</p></sec><sec><title>Бударина О</title><p>Бударина О.В. — концепция и дизайн исследования;</p></sec><sec><title>Железняк Е</title><p>Железняк Е.В., Князева Т.Д., Маковецкая А.К., Коганова З.И. — измерение биохимических и иммунологических показателей в пробах слюны детей;</p></sec><sec><title>Сабирова З</title><p>Сабирова З.Ф., Шипулина З.В. — оценка экспозиций.</p><p>Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование проведено в рамках выполнения Госзадания ФГБУ «ЦСП» ФМБА России.</p></sec><sec><title>Поступила</title><p>Поступила: 26.07.2021 / Принята к печати: 25.11.2021 / Опубликована: 08.04.2022 </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Horizontal transport of air pollutants by predominant winds plays an important role in the dispersion of emissions from their primary sources.</p><p>The purpose of this study is to assess the contribution of prevailing winds to changes of non-invasive markers in preschool children living in a small city at different distances and in different directions from the complex of agricultural processing enterprises.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Next markers were determined in mixed saliva samples of 112 children (aged 5–7 years) attending 6 kindergartens at distances of 1.74–5.74 km from the source of emissions toward the SSW, SSE and SE: the intensity of luminol-enchanced chemiluminescence (LC), secretory IgA, IL-1β, IL-6, IL-8 levels, and uric acid, α-amylase and N-acetyl-β-D-glucosaminidase activities. Based on the Meteoblue database, integral indicators of wind repeatebility (W, km/year) for winds, blowing towards the town from NNE, NNW and NW correspondingly, were calculated.</p></sec><sec><title>Results</title><p>Results. As a marker of the effect for multiple regression analysis, the intensity of LC in children’s saliva samples was chosen as having the most pronounced relationship with the distances between kindergartens and the source of emissions (R = –0.524; p = 7•10–9). The distances were shown to explain 49% of the total variance of LC intensity (p = 3•10–8), whereas the transfer of emissions with prevailing winds explains 16% of the total variance (p = 0.058). The resulting 3D model is in good agreement with previously conflicting data for two equidistant kindergartens having significant differences in children LC intensity, since corresponding wind repeatebilities differ twofold.</p></sec><sec><title>Limitations</title><p>Limitations. To develop the 3D model, archival data were used, with the theoretical possibility of planning a population survey with a more complete coverage of the wind rose points.</p></sec><sec><title>Conclusion</title><p>Conclusion. The results obtained indicate that it is promising to assess the contribution of prevailing winds when analyzing the data of human health in the industrial areas.</p></sec><sec><title>Contributions</title><p>Contributions: </p></sec><sec><title>Khripach L</title><p>Khripach L.V. — research concept and design, determination of biochemical and immunological indices in saliva samples, wind data adaptation, statistical analysis, interpretation and writing of the manuscript;</p></sec><sec><title>Budarina O</title><p>Budarina O.V. — research concept and design;</p></sec><sec><title>Zheleznyak E</title><p> Zheleznyak E.V., Knyazeva T.D., Makovetskaya A.K., Koganova Z.I. — determination of biochemical and immunological indices in saliva samples;</p></sec><sec><title>Sabirova Z</title><p>Sabirova Z.F., Shipulina Z.V. — evaluation of expositions.</p><p>All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Acknowledgement</title><p>Acknowledgement. The study had no sponsorship.</p></sec><sec><title>Received</title><p>Received: July 26, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>загрязнение атмосферного воздуха</kwd><kwd>повторяемость и скорость ветра</kwd><kwd>дети</kwd><kwd>смешанная слюна</kwd><kwd>люминол-зависимая хемилюминесценция</kwd><kwd>ИЛ-1β</kwd><kwd>ИЛ-6</kwd><kwd>ИЛ-8</kwd><kwd>sIgA</kwd><kwd>двухфакторный регрессионный анализ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>outdoor air pollution</kwd><kwd>wind speed and direction</kwd><kwd>children</kwd><kwd>mixed saliva</kwd><kwd>luminol-enchanced chemiluminescence</kwd><kwd>IL-1β</kwd><kwd>IL-6</kwd><kwd>IL-8</kwd><kwd>sIgA</kwd><kwd>two-factor regression analysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The Particle Pollution Report. 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