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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2019-98-7-718-722</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-360</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНА ТРУДА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OCCUPATIONAL HEALTH</subject></subj-group></article-categories><title-group><article-title>Коморбидные состояния у больных вибрационной болезнью</article-title><trans-title-group xml:lang="en"><trans-title>Co-morbid conditions in the vibration disease patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6609-8923</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ямщикова</surname><given-names>Анастасия Валерьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Yamshchikova</surname><given-names>Anastasia V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Науч. сотр. лаб. прикладной нейрофизиологии, врач-невролог ФГБНУ «НИИ комплексных проблем гигиены и профессиональных заболеваний», 654041, Новокузнецк.</p><p>e-mail: anastyam@bk.ru</p></bio><bio xml:lang="en"><p>MD, researcher of the laboratory for applied neurophysiology, neurologist, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.</p><p>e-mail: anastyam@bk.ru</p></bio><email xlink:type="simple">anastyam@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2823-4074</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Флейшман</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Fleishman</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8003-036X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гидаятова</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Gidayatova</surname><given-names>M. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний»</institution></aff><aff xml:lang="en"><institution>Research Institute for Complex Problems of Hygiene and Occupational Diseases</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2020</year></pub-date><volume>98</volume><issue>7</issue><fpage>718</fpage><lpage>722</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ямщикова А.В., Флейшман А.Н., Гидаятова М.О., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ямщикова А.В., Флейшман А.Н., Гидаятова М.О.</copyright-holder><copyright-holder xml:lang="en">Yamshchikova A.V., Fleishman A.N., Gidayatova M.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/360">https://www.rjhas.ru/jour/article/view/360</self-uri><abstract><sec><title>Введение</title><p>Введение. Вибрационная болезнь – это профессиональное заболевание, основным этиологическим фактором которого является производственная вибрация. При вибрационной болезни нарушается деятельность многих систем организма (нервной, сосудистой, опорно-двигательной, эндокринной), что предрасполагает к развитию коморбидных состояний. </p><p>Цель исследования – на основе изучения частоты и структуры коморбидной патологии у больных вибрационной болезнью выявить зависимость полиморбидности от длительности стажа и степени тяжести вибрационной патологии, определить прогноз 10-летней выживаемости согласно индексу коморбидности Charlson.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведён ретроспективный анализ 175 историй болезней 83 пациентов клиники Научно-исследовательского института комплексных проблем гигиены и профессиональных заболеваний за период с 2013 по 2018 г. Все пациенты (мужчины 40–60 лет) подвергались воздействию вибрации в процессе трудовой деятельности более 10 лет. </p></sec><sec><title>Результаты</title><p>Результаты. Коморбидные состояния при вибрационной болезни выявлены у 90% пациентов. Наиболее частыми оказались гиперхолестеринемия – 52%, дорсопатии – 29%, артериальная гипертензия – 27%, нейросенсорная тугоухость – 24% и др. Полученные результаты подтверждают описанные ранее данные о преобладании коморбидных сердечно-сосудистых и обменных нарушений при вибрационной болезни, которые связаны патогенетическими механизмами. Индекс коморбидности Charlson в основной группе составил 2,6 ± 1,04. Выявлена средняя статистическая связь частоты полиморбидности (φ = 0,21) со степенью тяжести вибрационной болезни.</p></sec><sec><title>Заключение</title><p>Заключение. Подавляющее большинство больных вибрационной болезнью имеют коморбидную патологию. Более выраженная степень поражения при вибрационной патологии ассоциирована с полиморбидностью. Эта связь, вероятно, обусловлена взаимным утяжелением течения сопутствующих заболеваний.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Occupation vibration is the main etiological factor of the vibration disease. Vibration disease disrupts the activity of different systems of the body (nervous, vascular, musculoskeletal, endocrine systems, etc.) which predisposes to the development of co-morbid conditions. </p></sec><sec><title>Aim of the study</title><p>Aim of the study. Based on the studying the prevalence and the structure of co-morbid pathology in vibration disease patients to identify the dependence of a polymorbidity on the duration of work experience and severity of vibration pathology, determine a prognosis of “10-year survival” according to the Charlson co-morbidity index.</p></sec><sec><title>Material and methods</title><p>Material and methods. A retrospective analysis of 175 clinical charts of 83 patients of the clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases for the period from 2013 to 2018 was carried out. All patients (40-60 years old men) were exposed to vibration in the course of the occupational activity for more than 10 years. </p></sec><sec><title>Results</title><p>Results. Co-morbid conditions in vibration disease were found in 90% of the patients. There most frequent were hypercholesterolemia (52%), dorsopathy (29%), arterial hypertension (27%), sensorineural hearing loss (24%), etc. The results confirm the previously described data on the predominance of co-morbid cardiovascular and metabolic disorders in vibration disease, which are interrelated by pathogenetic mechanisms. The Charlson co-morbidity index in the study group was 2.6 ± 1.04. Average statistical association of the polymorbidity prevalence (φ = 0.21) with the severity of the vibration disease was revealed.</p></sec><sec><title>Conclusions</title><p>Conclusions. The vast majority of the vibration disease patients have co-morbid pathology. More severe damage in vibration pathology is associated with polymorbidity. This relationship is probably due to the mutual worsening of the course of associated diseases.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>вибрационная болезнь</kwd><kwd>сопутствующие заболевания</kwd><kwd>коморбидные состояния</kwd><kwd>коморбидность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>vibration disease</kwd><kwd>concomitant diseases</kwd><kwd>co-morbid conditions</kwd><kwd>co-morbidity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Артамонова В.Г., Колесова Е.Б., Кускова Л.В. Некоторые современные аспекты патогенеза вибрационной болезни. Мед. труда и пром. экол. 1999; (2): 1-3.</mixed-citation><mixed-citation xml:lang="en">Artamonova V.G., Kolesova E.B., Kuskova L.V. Some modern aspects of the pathogenesis of vibration disease. Meditsina truda i promyshlennaya ekologiya. 1999; (2): 1-3. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бабанов С.А., Татаровская Н.А. Вибрационная болезнь: современное понимание и дифференциальный диагноз. РМЖ: Рус. мед. ж. 2013; (35): 1777.</mixed-citation><mixed-citation xml:lang="en">Babanov C.A., Tatarovskaya N.A. Vibration disease: modern understanding and differential diagnosis. RMZh: Russkiy meditsinskiy zhurnal. 2013; (35): 1777. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Feinstein A.R. Pre-therapeutic classification of co-morbidity in chronic disease. J. Chronic Dis. 1970; 23(7): 455-68</mixed-citation><mixed-citation xml:lang="en">Feinstein A.R. Pre-therapeutic classification of co-morbidity in chronic disease. J. Chronic Dis. 1970; 23(7): 455-68.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Оганов Р.Г., Денисов И.Н., Симаненков В.И., Бакулин И.Г., Бакулина Н.В., Болдуева С.А. и др. Коморбидная патология в клинической практике. Клинические рекомендации. Кардиоваскуляр. терапия и профилакт. 2017; 16(6): 5-56.</mixed-citation><mixed-citation xml:lang="en">Oganov R.G., Denisov I.N., Simanenkov V.I., Bakulin I.G., Bakulina N.V., Boldueva S.A et al. Comorbidities in practice. Clinical guidelines. Kardiovaskulyarnaya terapiya i profilaktika. 2017; 16(6): 5-56. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Белялов Ф.И. Двенадцать тезисов коморбидности. Клин. мед. 2009; 87(12): 69-71.</mixed-citation><mixed-citation xml:lang="en">Belyalov F.I. Twelve theses of comorbidity. Klinicheskaya meditsina. 2009; 87(12): 69-71. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Нургазизова А.К. Происхождение, развитие и современная трактовка понятий «коморбидность» и «полиморбидность». Казан. мед. ж. 2014; 95(2): 292-6.</mixed-citation><mixed-citation xml:lang="en">Nurgazizova A.K. The origin, development and current concepts of “comorbidity” and “polymorbidity”. Kazanskiy meditsinskiy zhurnal. 2014; 95(2): 292-6. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Вёрткин А.Л., Румянцев М.А., Скотников А.С. Коморбидность в клинической практике. Часть 1. Арх. внутр. мед. 2011; (2): 16-20. https://doi.org/10.20514/2226-6704-2011-0-2-20-24</mixed-citation><mixed-citation xml:lang="en">Vertkin A.L., Rumyantsev M.A., Skotnikov A.S. Comorbidity in clinical practice. Part 1. Arkhiv vnutrenney meditsiny. 2011; (2): 16-20. https://doi.org/10.20514/2226-6704-2011-0-2-20-24.(in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dzhambov A.M., Dimitrova D.D. Heart disease attributed to occupational noise, vibration and other co-exposure: Self-reported population-based survey among Bulgarian workers. Med. Pr. 2016; 67(4): 435-45. doi:10.13075/mp.5893.00437</mixed-citation><mixed-citation xml:lang="en">Dzhambov A.M., Dimitrova D.D. Heart disease attributed to occupational noise, vibration and other co-exposure: Self-reported population-based survey among Bulgarian workers. Med. Pr. 2016; 67(4): 435-45. doi:10.13075/mp.5893.00437.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Миронова Т.Ф., Давыдова Е.В., Уточкина И.М., Калмыкова А.В., Соколова Т.А. Возможности клинического анализа вариабельности сердечного ритма при профессиональных заболеваниях. Вестн. Челяб. обл. клин. больницы. 2012; (1): 20-4.</mixed-citation><mixed-citation xml:lang="en">Mironova T.F., Davydova E.V., Utochkina I.M., Kalmykova A.V., Sokolova T.A. Possibilities of a clinical analysis of heart rate variability in occupational diseases. Vestnik Chelyabinskoy oblastnoy klinicheskoy bol’nitsy. 2012; (1): 20-4. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Третьяков С.В., Шпагина Л.А. Перспективы изучения структурно-функционального состояния сердечно-сосудистой системы у больных вибрационной болезнью в сочетании с артериальной гипертензией. Мед. труда и пром. экол. 2017; (12): 30-4.</mixed-citation><mixed-citation xml:lang="en">Tret’yakov S.V., Shpagina L.A. Prospects of studying structural and functional state of cardiovascular system in vibration disease patients with arterial hypertension. Meditsina truda i promyshlennaya ekologiya. 2017; (12): 30-4. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Панев Н.И., Коротенко О.Ю., Захаренков В.В., Филимонов С.Н., Матвеева О.В., Родин С.И. и др. Распространенность сердечно-сосудистой патологии у больных вибрационной болезнью. В кн.: Экологические и социально-гигиенические аспекты здоровья населения Сибири: Материалы 52-ой научно-практической конференции «Гигиена, организация здравоохранения и профпатология» и семинара «Актуальные вопросы современной профпатологии». Новокузнецк; 2017: 140-4.</mixed-citation><mixed-citation xml:lang="en">Panev N.I., Korotenko O.Yu., Zakharenkov V.V., Filimonov S.N., Matveeva O.V., Rodin S.I. et al. Prevalence of cardiovascular disease in vibration disease patients. In: Ecological and social-hygienic aspects of health of the population of Siberia: Materials of the 52nd scientific and practical conference “Hygiene, organization of healthcare and occupational pathology” and seminar “Actual issuesof modern occupational pathology” [Ekologicheskie i sotsial’no-gigienicheskie aspekty zdorov’ya naseleniya Sibiri: Materialy 52-oy nauchno-prakticheskoy konferentsii “Gigiena, organizatsiya zdravookhraneniya i profpatologiya” i seminara “Aktual’nye voprosy sovremennoy profpatologii”]. Novokuznetsk; 2017: 140-4. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьмина О.Ю. Клинико-эпидемиологические особенности метаболического синдрома у больных профессиональными заболеваниями. Международный эндокринологический журнал. 2011; (4): 154-60.</mixed-citation><mixed-citation xml:lang="en">Kuzmina O.Yu. Clinical and epidemiological features of the metabolic syndrome in patients with occupational diseases. Mezhdunarodnyy endokrinologicheskiy zhurnal. 2011; (4): 154-60. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Паначева Л.А., Платонова Е.А., Кузнецова Г.В. Частота и клинические проявления метаболического синдрома при вибрационной болезни. Мед. труда и пром. экол. 2011; (10): 36-9.</mixed-citation><mixed-citation xml:lang="en">Panacheva L.A., Platonova E.A., Kouznetsova G.V. Prevalence and clinical manifestations of metabolic syndrome in vibration disease. Meditsina truda i promyshlennaya ekologiya. 2011; (10): 36-9. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Лапко И.В., Кирьяков В.А., Павловская Н.А., Антошина Л.И., Ошкодеров О.А. Влияние производственной вибрации на развитие инсулинорезистентности и сахарного диабета второго типа. Мед. труда и пром. экол. 2017; (2): 30-3.</mixed-citation><mixed-citation xml:lang="en">Lapko I.V., Kir’yakov V.A., Pavlovskaya N.A., Antoshina L.I., Oshkoderov O.A. Influence of occupational vibration on development of resistance to insulin and of II type diabetes mellitus. Meditsina truda i promyshlennaya ekologiya. 2017; (2): 30-3. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Кирьяков В.А., Сухова А.В., Новикова А.В. Вопросы коморбидности андрогенодефицита и соматической патологии у больных вибрационной болезнью. Мед. труда и пром. экол. 2014; (1): 26-30.</mixed-citation><mixed-citation xml:lang="en">Kir’yakov V.A., Sukhova A.V., Novikova A.V. Problems of androgen deficiency associated with somatic diseases in vibration disease patients. Meditsina truda i promyshlennaya ekologiya. 2014; (1): 26-30. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ефремова Е.В., Шутов А.М., Серов В.А., Мензоров М.В., ред. Коморбидность в клинической медицине: учебно-методическое пособие. Ульяновск: УлГУ; 2016.</mixed-citation><mixed-citation xml:lang="en">Kim J., Lee W., Won J-U, Yoon J-H, Seok H., Kim Y-K, et al. The relationship between occupational noise and vibration exposure and headache/eyestrain, based on the fourth Korean Working Condition Survey (KWCS). PLoS ONE 2017; 12(5): e0177846. https://doi.org/10.1371/journal.pone.0177846.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Huntley A.L., Johnson R., Purdy S., Valderas J.M., Salisbury C. Measures of multi-morbidity and morbidity burden for use in primary care and community settings: a systematic review and guide. Ann. Fam. Med. 2012; 10(2): 134-41. https://doi.org/10.1370/afm.1363</mixed-citation><mixed-citation xml:lang="en">Efremova E.V., Shutov A.M., Serov V.A., Menzorov M.V., eds. Comorbidity in clinical medicine: educational and methodical manual [Komorbidnost’ v klinicheskoy meditsine: uchebno-metodicheskoe posobie]. Ulyanovsk: UlGU; 2016. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Charlson M.E., Pompei P., Ales K.L., McKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 1987; 40(5): 373-83.</mixed-citation><mixed-citation xml:lang="en">Huntley A.L., Johnson R., Purdy S., Valderas J.M., Salisbury C. Measures of multi-morbidity and morbidity burden for use in primary care and community settings: a systematic review and guide. Ann. Fam. Med. 2012; 10(2): 134-41. https://doi.org/10.1370/afm.1363</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jani B.D., Hanlon P., Nicholl B.I., McQueenie R., Gallacher K.I., Lee D., et al. Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort. BMC Medicine. 2019; 17: 74. https://doi.org/10.1186/s12916-019-1305-x</mixed-citation><mixed-citation xml:lang="en">Charlson M.E., Pompei P., Ales K.L., McKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 1987; 40(5): 373-83.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Белялов Ф.И., ред. Лечение внутренних болезней в условиях коморбидности. Иркутск: РИО ИГМАПО; 2013</mixed-citation><mixed-citation xml:lang="en">Jani B.D., Hanlon P., Nicholl B.I., McQueenie R., Gallacher K.I., Lee D., et al. Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort. BMC Medicine. 2019; 17: 74. https://doi.org/10.1186/s12916-019-1305-x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace E., Salisbury C., Guthrie B., Lewis C., Fahey T., Smith S.M. Managing patients with multimorbidity in primary care. BMJ. 2015; 350: h176. https://doi.org/10.1136/bmj.h176</mixed-citation><mixed-citation xml:lang="en">Belyalov F.I., ed. Treatment of internal diseases under comorbidity [Lechenie vnutrennikh bolezney v usloviyakh komorbidnosti]. Irkutsk: RIO IGMAPO; 2013. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Смертность населения в трудоспособном возрасте. URL: http://www.gks.ru/free_doc/new_site/population/demo/smert.htm (дата обращения: 12 апреля 2019)</mixed-citation><mixed-citation xml:lang="en">Wallace E., Salisbury C., Guthrie B., Lewis C., Fahey T., Smith S.M. Managing patients with multimorbidity in primary care. BMJ. 2015; 350: h176. https://doi.org/10.1136/bmj.h176</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mortality of the population of employable age. Available at: http://www.gks.ru/free_doc/new_site/population/demo/smert.htm (accessed 12 April 2019) (in Russian)</mixed-citation><mixed-citation xml:lang="en">Mortality of the population of employable age. Available at: http://www.gks.ru/free_doc/new_site/population/demo/smert.htm (accessed 12 April 2019) (in Russian)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
