medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2024-103-4-382-390ntnhrrmedlit-3985Research ArticleПРОФИЛАКТИЧЕСКАЯ ТОКСИКОЛОГИЯ И ГИГИЕНИЧЕСКОЕ НОРМИРОВАНИЕPREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATIONМеханизмы физиологического и токсического действия солей лития на организм (обзор литературы)Mechanisms of physiological and toxic effects of lithium salts on the body (literature review)https://orcid.org/0000-0002-0545-631XГороховаЛариса ГеннадьевнаGorokhovaLarisa G.

Канд. биол. наук, вед. науч. сотр. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия; доцент каф. естественнонаучных дисциплин Кузбасского гуманитарно-педагогического института ФГБОУ ВО «КГУ», 654041, Новокузнецк, Россия

e-mail: ponomarikova@mail.ru

MD, PhD, DSci., Leading researcher, Lab. molecular genetic and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation; Associate Professor of the department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

e-mail: ponomarikova@mail.ru

ponomarikova@mail.ruhttps://orcid.org/0000-0002-4797-7842ЖуковаАнна ГеннадьевнаZhukovaAnna G.

Доктор биол. наук, доцент, зав. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия, зав. каф. естественнонаучных дисциплин Кузбасского гуманитарно-педагогического института ФГБОУ ВО «КГУ», 654041, Новокузнецк, Россия

MD, PhD, DSci., Associate Professor, Head of the Lab. of molecular genetics and experimental research of Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation, Head of the Department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

noemail@neicon.ruhttps://orcid.org/0000-0002-1127-6980МихайловаНадежда НиколаевнаMikhailovaNadezhda N.

Доктор биол. наук, профессор, гл. науч. сотр. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия

MD, PhD, DSci., Professor, Chief researcher of the Lab. of molecular genetics and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, 654041, Novokuznetsk, Russian Federation

noemail@neicon.ruhttps://orcid.org/0000-0003-2512-2541КорсаковаТатьяна ГеоргиевнаKorsakovaTatyana G.

Канд. биол. наук, вед. науч. сотр. лаб. экологии человека и гигиены окружающей среды ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия

MD, PhD, leading researcher of the Lab. of Human Ecology and Environmental Hygiene of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation

e-mail: ecologia_nie@mail.ru

noemail@neicon.ruФГБНУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний»; Кузбасский гуманитарно-педагогический институт ФГБОУ ВО «Кемеровский государственный университет»РоссияResearch Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”Russian FederationФГБНУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний»РоссияResearch Institute for Complex Problems of Hygiene and Occupational DiseasesRussian Federation2024220520241034382390Copyright © Горохова Л.Г., Жукова А.Г., Михайлова Н.Н., Корсакова Т.Г., 20242024Горохова Л.Г., Жукова А.Г., Михайлова Н.Н., Корсакова Т.Г.Gorokhova L.G., Zhukova A.G., Mikhailova N.N., Korsakova T.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/3985

Изучение влияния различных химических элементов на организм человека является актуальным направлением, поскольку позволяет определять закономерности распределения и миграции этих элементов в тканях, а также их роль в развитии специфических патологий. Среди неорганических химических соединений особое место занимают литиевые соли, которые широко применяются в промышленности, сельском хозяйстве и медицине. Поиск и отбор литературных источников для выявления физиологических эффектов и особенностей токсического действия солей лития на организм человека и экспериментальных животных осуществлён с использованием библиографических баз данных Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, РИНЦ, Cyberleninka. Анализ данных показал, что соли лития относятся к умеренно опасным веществам (III класс опасности) и в высоких концентрациях оказывают повреждающее действие на функции нервной системы, почек, щитовидной и паращитовидных желёз.

Участие авторов

Участие авторов:Горохова Л.Г. — концепция исследования, сбор материала, написание текста;Жукова А.Г. — сбор материала, написание текста;Михайлова Н.Н. — редактирование;Корсакова Т.Г. — сбор материала.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Конфликт интересов

Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Поступила

Поступила: 15.12.2023 / Поступила после доработки: 11.03.2024 / Принята к печати: 09.04.2024 / Опубликована: 08.05.2024

The study of the influence of various chemical elements on the human body is an important direction because it allows determining the patterns of the distribution and migration of these elements in tissues, as well as their role in the development of specific diseases. Among inorganic chemical compounds, a special place is occupied by lithium salts, which are widely used in industry, agriculture, and medicine. The search and selection of literature sources to identify the physiological effects and characteristics of the toxic effects of lithium salts on the human body and experimental animals was carried out using the bibliographic databases: Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, RSCI, Cyberleninka. Data analysis has showed lithium salts to be classified as moderately hazardous substances (hazard class 3) and in high concentrations have a damaging effect on the functions of the nervous system, kidneys, thyroid and parathyroid glands.

Contribution

Contribution:Gorokhova L.G. — the concept of the study, collection of material, writing the text;Zhukova A.G. — collection of material, writing the text;Mikhailova N.N. — editing;Korsakova T.G. — collection of material.All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement

Acknowledgement. The study had no sponsorship.

Received

Received: February 15, 2024 / Revised: March 11, 2024 / Accepted: April 9, 2024 / Published: May 8, 2024

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The authors declare that there are no conflicts of interest present.