medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2024-103-7-724-736fcmrofmedlit-4251Research ArticleГИГИЕНА ПИТАНИЯFOOD HYGIENEРоль продуктов питания в повышении устойчивости организма к действию наночастиц (обзор литературы)The role of food products in increasing the body’s resistance to the action of nanoparticles (literature review)https://orcid.org/0000-0003-2677-0479РябоваЮлия ВладимировнаRyabovaYuliya V.

Канд. мед. наук, зав. лаб. научных основ биологической профилактики ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург, Россия

e-mail: ryabovaiuvl@gmail.com

MD, PhD, head of the Laboratory of Scientific Foundations of Bioprophylaxis, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federation

e-mail: ryabovaiuvl@gmail.com

ryabovaiuvl@gmail.comhttps://orcid.org/0000-0002-8284-0008ШабардинаЛада ВладимировнаShabardinaLada V.

Мл. науч. сотр. отд. токсикологии и биопрофилактики, ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург, Россия

e-mail: lada.shabardina@mail.ru

Junior researcher, Department of Toxicology and Bioprophylaxis, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federatio

e-mail: lada.shabardina@mail.ru

lada.shabardina@mail.ruhttps://orcid.org/0000-0002-0097-7845МинигалиеваИльзира АмировнаMinigalievaIlzira A.

Доктор биол. наук, зав. отд. токсикологии и биологической профилактики, ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург, Россия

e-mail: ilzira-minigalieva@yandex.ru

MD, PhD, DSci., head of the Department of Toxicology and Bioprophylaxis, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federation

e-mail: ilzira-minigalieva@yandex.ru

ilzira-minigalieva@yandex.ruhttps://orcid.org/0000-0002-1743-7642СутунковаМарина ПетровнаSutunkovaMarina P.

Доктор мед. наук, директор ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург, Россия; доцент, и. о. зав. каф. гигиены и медицины труда ФГБОУ ВО УГМУ Минздрава России, 620014, Екатеринбург, Россия

e-mail: sutunkova@ymrc.ru

MD, PhD, DSci, Director, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federation; assoc. professor, acting head of the Department of Occupational Health and Medicine, Ural State Medical University, Yekaterinburg, 620028, Russian Federation

e-mail: sutunkova@ymrc.ru

sutunkova@ymrc.ruФБУН «Екатеринбургский медицинский–научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial WorkersRussian FederationФБУН «Екатеринбургский медицинский–научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека; ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers; Ural State Medical UniversityRussian Federation2024310720241037724736Copyright © Рябова Ю.В., Шабардина Л.В., Минигалиева И.А., Сутункова М.П., 20242024Рябова Ю.В., Шабардина Л.В., Минигалиева И.А., Сутункова М.П.Ryabova Y.V., Shabardina L.V., Minigalieva I.A., Sutunkova M.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/4251

Многолетние научные исследования ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора показали, что в качестве встречного пути медико-биологической профилактики рассматривается возможность повышения резистентности организма (особенно в группах риска) к потенциально опасным уровням вредной экспозиции. В результате этих исследований были разработаны биопрофилактические комплексы, содержащие витаминно-минеральные компоненты. Важной закономерностью, выявленной в проведённых исследованиях, является то, что комплексное применение биопрофилактических средств с не полностью совпадающей направленностью и разными механизмами действия даёт более выраженный профилактический эффект, чем отдельные биопротекторы. В большом числе экспериментов команда ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора с успехом испытала способы повышения устойчивости организма к ряду вредных веществ: минеральные пыли (диоксид кремния, асбест, монацит), соли и оксиды свинца, мышьяка, хрома, марганца, фтора, ванадия, никеля, органические вещества (фенол, формальдегид, бенз(а)пирен), различные комбинации металлов и их соединений, в том числе и наночастиц (Pb и Cd; Pb и F; Pb, As, Cu, Cd; Pb, Cr, As, Cd; Pb, Cr, Se, As, Ni; Mn, Al, Ti, Si и др.), характерных для окружающей среды в конкретных городах или для воздуха рабочих помещений конкретных производств. Авторы утверждают, что опыт исследователей ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора в этой области уникален и что некоторые результаты были получены впервые, особенно в отношении наночастиц. Вместе с тем роль натуральных пищевых компонентов в повышении устойчивости организма к негативному действию наночастиц изучена недостаточно. Эта статья представляет собой обзор публикаций в различных журналах других исследователей, изучающих применение натуральных компонентов для повышения устойчивости организма к вредному действию наночастиц.

Цель исследования – провести обзор литературы о способности натуральных пищевых компонентов повышать устойчивость организма к действию наночастиц (НЧ) для дальнейшего углубления теоретических и методических основ системы биологической профилактики.

Выполнен научный обзор исследований на русском и английском языках с использованием информационных порталов и платформ PubMed, Google Scholar, eLibrary, CyberLeninka, Scopus за период 2014–2023 гг. Поиск проводили по ключевым словам: «добавки», «наночастицы», «токсичность», «повышение устойчивости». Были включены оригинальные исследования. Отбор статей осуществляли по принципу наличия в них сведений о способности натуральных пищевых добавок снижать негативные эффекты интоксикации наночастицами (от 1 до 100 нм). После первичного анализа более 200 выявленных статей было отобрано 60 полнотекстовых материалов, из них более 60% было подготовлено исследовательскими коллективами из Египта.

Показана возможность применения натуральных пищевых компонентов для повышения устойчивости живых организмов к негативному действию НЧ. Для этих целей предлагается использовать специи и части растений (куркуму, семена рукколы, водоросли), каротиноиды (β-каротин, ликопин, кроцин), растительные экстракты (экстракт гинкго двулопастного, цикория, коры китайской корицы, зелёного чая, граната и др.), эфирные масла (чабреца, корицы, базилика и др.), соки (свёклы, граната) и флавоноиды. Упомянутые вещества снижали выраженность нейро-, кардио-, репро-, нефро- и гепатотоксических эффектов НЧ.

Заключение

Заключение. Представленный обзор литературы позволяет выявить наиболее эффективные способы повышения устойчивости живого организма к действию НЧ с помощью натуральных компонентов пищи.

Участие авторов

Участие авторов:Рябова Ю.В. – концепция и дизайн исследования, написание текста, редактирование;Шабардина Л.В. – сбор и обработка материала, написание текста;Минигалиева И.А. – научное редактирование статьи;Сутункова М.П. – научное консультирование.Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Конфликт интересов

Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Поступила

Поступила: 22.05.2023 / Поступила после доработки: 24.05.2024 / Принята к печати: 2024 / Опубликована: 31.07.2024

Long-term scientific research of the Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers has shown the feasibility of increasing the body resistance (especially that in risk groups) to potentially dangerous levels of adverse exposure to be being considered as a counter path to biomedical prevention. As a result, “bioprophylactic complexes” containing vitamin and mineral components have been developed. An important pattern identified in the conducted studies is that the complex use of bioprophylactic agents with not completely identical directions and different mechanisms of action gives a more pronounced preventive effect than individual bioprotectors. In a large number of experiments, the team of the above mentioned Center successfully tested ways to increase the body resistance to such pollutants as mineral dusts (silicon dioxide, asbestos, monazite); salts and oxides of lead, arsenic, chromium, manganese, fluorine, vanadium, and nickel; organic substances (phenol, formaldehyde, benzo(a)pyrene); various combinations of metals and their compounds, including nanoparticles, e.g., Pb and Cd; Pb and F; Pb, As, Cu, Cd; Pb, Cr, As, Cd; Pb, Cr, Se, As, Ni; Mn, Al, Ti, Si, etc., found in the environment of regional cities and/or the workplace air of certain industries. We claim that our experience in this area is unique and that some results have been obtained for the first time, especially with regard to nanoparticles. The role of nutritional components in increasing the body resistance to adverse effects of nanoparticles is still poorly studied. Here we present a review of publications by other researchers on the use of natural components to increase the body resistance to detrimental effects of nanoparticles on health .

Our purpose was to review available sources on the ability of natural components to increase the resistance of the human body to effects of nanoparticles to further deepen theoretical and methodological foundations of the system of biological prophylaxis.

We reviewed Russian and English-language original research reports published in 2014–2023 and found in PubMed, Google Scholar, e-Library, CyberLeninka, and Scopus databases using the following keywords: additives, nanoparticles, toxicity, and resistance enhancement. The inclusion criterion was information on the ability of natural food additives to mitigate unfavourable effects of poisoning with nanoparticles sized 1 to 100 nm. Of more than 200 sources originally found, 60 full-text papers were selected, of which over 60 % were written by Egyptian research teams.

We revealed the possibility of using certain natural foods and components, i.e. spices and plant parts (turmeric, arugula seeds, algae), carotenoids (β-carotene, lycopene, crocin), plant extracts (ginkgo biloba extract, chicory, Chinese cinnamon bark, green tea, pomegranate, etc.), essential oils (thyme, cinnamon, basil, etc.), juices (beets, pomegranate), and flavonoids, to increase the resistance of a living organism to toxicity of nanoparticles and to reduce severity of their neuro-, cardio-, repro-, nephro- and hepatotoxic effects.

Conclusion

Conclusion. This literature review describes the most effective natural foods and their components enhancing the resistance of a living organism to adverse effects of nanoparticles.

Contributions

Contributions:Ryabova Yu.V. – study conception and design, draft manuscript preparation, editing;Shabardina L.V. – data collection and processing, draft manuscript preparation;Minigalieva I.A. – scientific editing;Sutunkova M.P. – scientific advice.All authors – approval of the final version of the manuscript and responsibility for the integrity of all its parts.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement

Acknowledgement. The study had no sponsorship.

Received

Received: May 22, 2023 / Revised: May 25, 2024 / Accepted: June 19, 2024 / Published: July 31, 2024

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The authors declare that there are no conflicts of interest present.