medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2019-98-11-1262-1266medlit-451Research ArticleГИГИЕНА ДЕТЕЙ И ПОДРОСТКОВHYGIENE OF CHILDREN AND ADOLESCENTSВозрастные особенности экскреции карбонильных соединений с мочой у детей на неэкспонированной территорииAge features of the excretion of carbonilic compounds with urine in children in unexposed territoryhttps://orcid.org/0000-0002-9961-6408ЖурбаОльга МихайловнаZhurbaOlga M.

Кандидат биол. наук, зав. лаб. аналитической экотоксикологии и биомониторинга, ФГБНУ «Восточно-Сибирский институт медико-экологических исследований», 665827, Ангарск.

e-mail: zhurba99@gmail.com

MD, Ph.D., head of the laboratory of analytical ecotoxicology and biomonitoring of the East-Siberian Institution of Medical and Ecological Research, Angarsk, 665827, Russian Federation.

e-mail: zhurba99@gmail.com

zhurba99@gmail.comhttps://orcid.org/0000-0001-7218-2147ЕфимоваН. В.EfimovaN. V.noemail@neicon.ruhttps://orcid.org/0000-0003-4980-5304АлексеенкоА. Н.AlekseenkoA. N.noemail@neicon.ruhttps://orcid.org/0000-0001-7848-6432МериновА. В.MerinovA. V.noemail@neicon.ruФедеральное государственное бюджетное научное учреждение «Восточно-Сибирский институт медико-экологических исследований»East-Siberian Institute of Medical and Ecological Research201914102020981112621266Copyright © Журба О.М., Ефимова Н.В., Алексеенко А.Н., Меринов А.В., 20202020Журба О.М., Ефимова Н.В., Алексеенко А.Н., Меринов А.В.Zhurba O.M., Efimova N.V., Alekseenko A.N., Merinov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/451Введение

Введение. Карбонильные соединения (КС) являются поллютантами, воздействующими на население и занимающие исключительное положение в различных сферах деятельности человека. Значительным источником КС является табачный дым.

Материал и методы

Материал и методы. Методом газовой хроматографии проанализированы пробы мочи 278 детей. Дополнительно изучены зависимости содержания КС от вредных химических воздействий в бытовых условиях: активного и пассивного курения. Оценка влияния курения на выделение формальдегида (ФД) проведена с помощью критерия «хи-квадрат» для таблицы 3 × 3.

Результаты

Результаты. Получены результаты о содержании КС в моче в нескольких возрастных группах. Показано, что концентрации ФД в целом находились в диапазоне от 1,2 до 207,1 мкг/дм3. Наибольшие значения отмечались у детского населения возрастной группы до 7 лет и в группе 15–17 лет. Для представителей 1-й (до 7 лет) и 3-й (15–17 лет) возрастных групп концентрации ацетальдегида и ацетона находились в диапазоне: для ацетальдегида от 4 до 179,7 мкг/дм3, ацетона от 0,35 до 11,95 мкг/дм3. Выявлена статистически значимая прямая зависимость между активным курением и содержанием ФД в моче (rsp = 0,24, р = 0,033); обратная – с содержанием ацетона (rsp = 0,23, р = 0,042) и обратная корреляционная связь содержания ацетальдегида и пассивного курения (rsp = 0,23, р = 0,038).

Заключение

Заключение. Выявлено наиболее высокое содержание формальдегида в моче в группах «до 7 лет» и «15–17 лет». Возрастных и гендерных различий концентраций ацетальдегида и ацетона не выявлено.

Introduction

Introduction. Carbonyl compounds (CC) are pollutants affecting the population and occupying an exceptional position in various fields of human activity. A significant source of CC is tobacco smoke.

Material and methods

Material and methods. Urine samples of 278 children were analyzed by the method of gas chromatography. Additionally, there were studied dependencies of the content of the CC on the harmful chemical effects in living conditions: active and passive smoking. The assessment of the effect of smoking on formaldehyde emissions (FD) was carried out using the chi-square test for a 3x3 table.

Results

Results. The results obtained on the content of CC in the urine in several age groups. FD concentrations, in general, were shown to be in the range from 1.2 to 207.1 μg/dm3. The highest values were observed in the children’s population of the age group up to 7 years and in the group of 15-17 years. For representatives of the 1st (up to 7 years) and 3rd (15–17 years) age groups, the concentrations of acetaldehyde and acetone were in the range: for acetaldehyde - from 4.0 to 179.7 µg/dm3, acetone - from 0.35 to 11.95 µg/dm3. A statistically significant direct relationship was found between active smoking and FD content in urine (rsp = 0.24, p = 0.033); the reverse is with acetone content (rsp = 0.23, p = 0.042), and the inverse correlation between acetaldehyde content and passive smoking (rsp = 0.23, p = 0.038).

Conclusion

Conclusion. The highest content of formaldehyde in the urine was found in groups “up to 7 years old” and “15–17 years old”. No age and gender differences in acetaldehyde and acetone concentrations were found.

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The authors declare that there are no conflicts of interest present.