medlitГигиена и санитарияHygiene and Sanitation0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0016-9900-2025-104-3-340-347jueqrwmedlit-4721Research ArticleМЕДИЦИНА ТРУДАOCCUPATIONAL HEALTHГенетические факторы риска развития вибрационной болезни (обзор литературы)Genetic risk factors for the development of vibration disease (literature review)https://orcid.org/0000-0002-7456-4787МухаммадиеваГузель ФанисовнаMukhammadiyevaGuzel F.

Канд. биол. наук, ст. науч. сотр. отд. токсикологии и генетики с экспериментальной клиникой лабораторных животных ФБУН «Уфимский НИИ медицины труда и экологии человека», 450106, Уфа, Россия

e-mail: ufniimt@mail.ru

PhD (Biology), Senior Researcher at the Department of Toxicology and Genetics with the Experimental Clinics for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: ufniimt@mail.ru

ufniimt@mail.ruhttps://orcid.org/0000-0002-6127-7703ШайхлисламоваЭльмира РадиковнаShaihlislamovaElmira R.

Канд. мед. наук, директор ФБУН «Уфимский НИИ медицины труда и экологии человека», 450106, Уфа, Россия

e-mail: fbun@uniimtech.ru

PhD (Medicine), Director, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: fbun@uniimtech.ru

fbun@uniimtech.ruhttps://orcid.org/0000-0002-1962-2323КаримовДенис ДмитриевичKarimovDenis D.

Канд. биол. наук, ст. науч. сотр. отд. токсикологии и генетики с экспериментальной клиникой лабораторных животных ФБУН «Уфимский НИИ медицины труда и экологии человека», 450106, Уфа, Россия

e-mail: lich-tsar@mail.ru

PhD (Biology), Senior Researcher at the Department of Toxicology and Genetics with the Experimental Clinics for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: lich-tsar@mail.ru

lich-tsar@mail.ruhttps://orcid.org/0000-0003-0039-6757КаримовДенис ОлеговичKarimovDenis O.

Канд. мед. наук, зав. отд. токсикологии и генетики с экспериментальной клиникой лабораторных животных ФБУН «Уфимский НИИ медицины труда и экологии человека», 450106, Уфа, Россия

e-mail: karimovdo@gmail.com

PhD (Medicine), Head of the Department of Toxicology and Genetics with the Experimental Clinics for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: karimovdo@gmail.com

karimovdo@gmail.comФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»РоссияUfa Research Institute of Occupational Health and Human EcologyRussian FederationФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»; ФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияUfa Research Institute of Occupational Health and Human Ecology; Bashkir State Medical UniversityRussian FederationФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»; ФГБНУ «Национальный научно-исследовательский институт общественного здоровья имени Н.А. Семашко»РоссияUfa Research Institute of Occupational Health and Human Ecology; N.A. Semashko National Research Institute of Public Health»Russian Federation2025310320251043340347Copyright © Мухаммадиева Г.Ф., Шайхлисламова Э.Р., Каримов Д.Д., Каримов Д.О., 20252025Мухаммадиева Г.Ф., Шайхлисламова Э.Р., Каримов Д.Д., Каримов Д.О.Mukhammadiyeva G.F., Shaihlislamova E.R., Karimov D.D., Karimov D.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rjhas.ru/jour/article/view/4721

Вибрационная болезнь (ВБ) входит в число лидирующих в структуре профессиональной патологии, характеризуется сложной патогенетической структурой, полисиндромностью, хроническим течением, устойчивостью к лечению, нередко приводит к снижению работоспособности и инвалидизации пациентов. Среди возможных факторов риска развития ВБ исследователи особое внимание уделяют генетической предрасположенности. В настоящей работе обобщены результаты современных исследований по идентификации генов-кандидатов и их полиморфизмов, обусловливающих предрасположенность к возникновению ВБ и других болезней, имеющих схожие патогенетические механизмы. Поиск литературы осуществляли в англоязычных текстовых базах PubMed, Scopus, Web of Science и в научной электронной библиотеке eLIBRARY.ru (РИНЦ). В обзоре рассмотрены полиморфизмы некоторых генов I фазы детоксикации ксенобиотиков, семейства катионных каналов с транзиторным рецепторным потенциалом, супероксиддисмутаз, глутатионпероксидаз, эпоксидгидролаз, матриксных металлопротеиназ, каспаз, эндотелиальной синтазы оксида азота, белков теплового шока, фолатного цикла, сиртуинов, эндотелинов, ангиотензин-превращающего фермента, генов рецептора серотонина, а также генов интерлейкинов и фактора некроза опухолей. Согласно литературным данным, на формирование и развитие ВБ влияет сложный механизм взаимодействия разных генов. Результаты молекулярно-генетических исследований подтверждают патогенетическую сложность и полиморфность симптоматики ВБ. Требуются дальнейший поиск и изучение новых генетических предикторов развития ВБ. Полученные данные дадут возможность не только расширить понимание патогенеза и механизмов развития ВБ, но и предоставят инструменты для прогнозирования, персонализированного подхода к профилактике и лечению.

Участие авторов

Участие авторов: Мухаммадиева Г.Ф. – концепция и дизайн обзора, сбор и обработка данных, написание текста, редактирование; Шайхлисламова Э.Р. – концепция и дизайн обзора, редактирование; Каримов Д.Д. – сбор и обработка данных; Каримов Д.О. – концепция и дизайн обзора, редактирование. Все соавторы – ответственность за целостность всех частей статьи, утверждение окончательного варианта статьи.

Конфликт интересов

Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.

Финансирование

Финансирование. Исследование выполнено в рамках отраслевой научно-исследовательской программы Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека на 2021–2025 гг. «Научное обоснование национальной системы обеспечения санитарно-эпидемиологического благополучия, управления рисками здоровью и повышения качества жизни населения России» (п. 2.2.9).

Поступила

Поступила: 05.08.2024 / Принята к печати: 03.12.2024 / Опубликована: 31.03.2025

Vibration disease (VD) occupies one of the leading places in occupational pathology. This disease is characterized by the complexity of pathogenetic mechanisms, polysyndromicity, chronic course, resistance to therapy, and often leads to disability and disablement in patients. Among the possible risk factors for the development of VD, the attention of researchers is paid to genetic predisposition. The work summarizes the results of modern research on the identification of candidate genes and their polymorphisms that determine predisposition to the occurrence of VD and a number of other diseases that have similar pathogenetic mechanisms. The literature search was carried out in the English text databases PubMed, Scopus, Web of Science and in the scientific electronic library eLIBRARY.ru (RSCI). The review examines polymorphisms of some genes of phase I of xenobiotic detoxification, a family of cation channels with transient receptor potential, superoxide dismutases, glutathione peroxidases, epoxide hydrolases, matrix metalloproteinases, caspases, endothelial nitric oxide synthase, heat shock proteins, folate cycle, sirtuins, endothelins, angiotensin-converting enzyme, serotonin receptor genes, as well as interleukins and tumor necrosis factor genes. Based on literature data, a complex mechanism of interaction between different genes can be assumed to be involved in the formation and development of VD. The results of molecular genetic studies confirm the pathogenetic complexity and polymorphism of the symptoms of VD. Further search and study of new genetic predictors of VD development is required. The data obtained will not only expand our understanding of the pathogenesis and mechanisms of VD development, but also provide tools for prediction and a personalized approach to prevention and treatment.

Contribution

Contribution: Muhammadiyeva G.F. – the concept and design of the study, collection and processing of material, writing text, editing; Shaihlislamova E.R. – the concept and design of the study, editing; Karimov D.D. – collection and processing of material; Karimov D.O. – the concept and design of the study, editing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Acknowledgment

Acknowledgment. The work was carried out within the framework of the industry research program of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare for 2021–2025. «Scientific justification for the national system for ensuring sanitary and epidemiological well-being, managing health risks and improving the quality of life of the Russian population» clause 2.2.9.

Received

Received: August 15, 2024 / Accepted: December 3, 2024 / Published: March 31, 2025

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The authors declare that there are no conflicts of interest present.