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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2025-104-10-1326-1333</article-id><article-id custom-type="edn" pub-id-type="custom">yuwkmk</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-5231</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИГИЕНА ПИТАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOOD HYGIENE</subject></subj-group></article-categories><title-group><article-title>Актуальные вопросы разработки специализированной пищевой продукции на основе молозива коровьего</article-title><trans-title-group xml:lang="en"><trans-title>Current issues of the development of specialized food products for dietary preventive and dietary therapeutic nutrition based on cow colostrum</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0209-9732</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмин</surname><given-names>Сергей Владимирович</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmin</surname><given-names>Sergey V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, директор ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Россия</p><p>e-mail: fncg@fncg.ru</p></bio><bio xml:lang="en"><p>DSc (Medicine), Professor, Director, Federal Scientific Center of Hygiene named after F.F. Erisman, Mytishchi, 141014, Russian Federation</p><p>e-mail: fncg@fncg.ru</p></bio><email xlink:type="simple">fncg@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6887-6776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сетко</surname><given-names>Андрей Геннадьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Setko</surname><given-names>Andrey G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, зав. отд. гигиены питания ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Россия</p><p>e-mail: Setko.AG@fncg.ru</p></bio><bio xml:lang="en"><p>DSc (Medicine), Professor, Head, Food hygiene department, Federal Scientific Center of Hygiene named after F.F. Erisman, Mytishchi, 141014, Russian Federation</p><p>e-mail: Setko.AG@fncg.ru</p></bio><email xlink:type="simple">Setko.AG@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2275-9347</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майзель</surname><given-names>Сергей Гершевич</given-names></name><name name-style="western" xml:lang="en"><surname>Mayzel</surname><given-names>Sergey G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор техн. наук, профессор, председатель Совета директоров ООО «Победа-1», 620027, Екатеринбург, Россия</p><p>e-mail: smayzel@gmail.com</p></bio><bio xml:lang="en"><p>DSc (Engineerung), professor, chairman, Board of directors of Pobeda-1 LLC, Yekaterinburg, 620027, Russian Federation</p><p>e-mail: smayzel@gmail.com</p></bio><email xlink:type="simple">smayzel@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6123-8782</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юскина</surname><given-names>Ольга Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Yuskina</surname><given-names>Olga N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. биол. наук, ведущ. науч. сотр. отд. гигиены питания ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Россия</p><p>e-mail: Yuskina.ON@fncg.ru</p></bio><bio xml:lang="en"><p>PhD (Biology), leading researcher, Food hygiene department, Federal Scientific Center of Hygiene named after F.F. Erisman, Mytishchi, 141014, Russian Federation</p><p>e-mail: Yuskina.ON@fncg.ru</p></bio><email xlink:type="simple">Yuskina.ON@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр гигиены имени Ф.Ф. Эрисмана» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Scientific Center of Hygiene named after F.F. Erisman</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Победа-1»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>OOO Pobeda-1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>11</month><year>2025</year></pub-date><volume>104</volume><issue>10</issue><fpage>1326</fpage><lpage>1333</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузьмин С.В., Сетко А.Г., Майзель С.Г., Юскина О.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кузьмин С.В., Сетко А.Г., Майзель С.Г., Юскина О.Н.</copyright-holder><copyright-holder xml:lang="en">Kuzmin S.V., Setko A.G., Mayzel S.G., Yuskina O.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/5231">https://www.rjhas.ru/jour/article/view/5231</self-uri><abstract><p>Сбалансированному питанию отводится ведущая роль в физиологическом развитии детей, поддержании здоровья населения, повышении качества и продолжительности жизни. Один из возможных способов нормализации питания населения – разработка и производство специализированной пищевой продукции (СПП) диетического профилактического и диетического лечебного питания. В обзоре представлены современные исследования, посвящённые разработке, качеству и безопасности СПП, изготавливаемой на основе молозива коровьего (МК).</p><p>Цель исследования – изучение разработки, оценки качества и безопасности специализированной пищевой продукции на основе молозива коровьего.</p><p>В работе применены теоретические методы оценки соответствия СПП на основе молозива коровьего обязательным требованиям. Объектами исследования служили полнотекстовые документы законодательных и нормативных актов Российской Федерации, ЕАЭС и других стран, источники научной литературы из электронных баз данных (eLIBRARY, PubMed, Scopus, Web of Science) в области производства и подтверждения соответствия СПП на основе молозива коровьего, а также материалы собственных многолетних исследований. Приведены сведения об отличительных признаках СПП на основе молозива коровьего, раскрыты аспекты качества и безопасности данной продукции.</p><sec><title>Заключение</title><p>Заключение. Проанализированы физико-химические свойства молозива, его состав и биологическая ценность, в том числе содержание иммуноглобулинов, факторов роста, витаминов и минеральных веществ. Обсуждаются особенности производства такой продукции, её влияние на здоровье потребителей, возможные риски и преимущества. Уделено внимание оценке соответствия продукции обязательным требованиям качества и безопасности. Сформулирован вывод о перспективах дальнейшего развития исследований и практического применения продуктов на основе МК в качестве специализированной пищевой продукции.</p></sec><sec><title>Участие авторов</title><p>Участие авторов: Кузьмин С.В. – научное руководство; Сетко А.Г. – сбор, анализ, обработка материалов, систематизация и обобщение данных литературы, редактирование; Майзель С.Г. – сбор, анализ материалов, редактирование; Юскина О.Н. – концепция и дизайн обзорно-аналитического исследования, сбор материала и обработка данных литературы, редактирование. Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех её частей.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование проведено без спонсорской поддержки.</p></sec><sec><title>Поступила</title><p>Поступила: 15.07.2025 / Принята к печати: 15.10.2025 / Опубликована: 14.11.2025</p></sec></abstract><trans-abstract xml:lang="en"><p>A balanced diet creates conditions for the physiological development in children, maintaining public health, and improving the quality and longevity of life. One of the possible ways to normalize the diet of the population is the development and production of specialized food products (SFP) for dietary preventive and dietary therapeutic nutrition. The review examines current research on the development, quality, and safety of SFP made on the basis of cow colostrum (CC).</p><sec><title>The purpose of the study</title><p>The purpose of the study. Study of issues of development, assessment of quality and safety of SFP based on CC.</p><p>The paper uses theoretical research methods for assessing the compliance of SFP based on CC with mandatory requirements. The objects of the research were full-text documents of legislative and regulatory acts of the Russian Federation, the EAEU and other countries, sources of scientific literature from electronic databases (e-library, Pubmed, Scopus, Web of Science) in the field of production and conformity assessment of SFP based on CC, as well as materials from our own long-term research. </p><p>Information about the distinctive features of SFP based on CC is provided, and aspects of the quality and safety of these products are disclosed.</p></sec><sec><title>Conclusion</title><p>Conclusion. The physicochemical properties of colostrum, its composition and biological value, including the content of immunoglobulins, growth factors, vitamins, and minerals, were analyzed. The specifics of the production of such products, their impact on consumer health, possible risks and benefits are discussed. Attention is paid to assessing the conformity of products with mandatory quality and safety requirements. A conclusion is formulated about the prospects for further development of research and practical application of CC-based products as SFP.</p></sec><sec><title>Contribution</title><p>Contribution: Kuzmin S.V. — scientific guidance; Setko A.G. — editing, collection, analysis, processing of materials, systematization and generalization of data from literary sources; Maizel S.G. — editing, collection, analysis of materials; Yuskina O.N. — editing, concept and design of review and analytical research, collection of material and processing data from literary sources. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Funding</title><p>Funding. The study had no sponsorship.</p></sec><sec><title>Received</title><p>Received: July 15, 2025 / Accepted: October 15, 2025 / Published: November 14, 2025</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>специализированная пищевая продукция</kwd><kwd>молозиво коровье</kwd><kwd>показатели качества и безопасности специализированной пищевой продукции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>specialized food products</kwd><kwd>cow colostrum</kwd><kwd>quality and safety indicators of specialized food products</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тутельян В.А., Никитюк Д.Б., Буряк Д.А., Акользина С.Е., Батурин А.К., Погожева А.В. и др. Качество жизни. Здоровье и питание: атлас. М.: Медицина; 2018.</mixed-citation><mixed-citation xml:lang="en">Tutelyan V.A., Nikityuk D.B., Buryak D.A., Akolzina S.E., Baturin A.K., Pogozheva A.V., et al. Quality of Life. Health and Nutrition: Atlas [Kachestvo zhizni. Zdorov’e i pitanie: atlas]. Moscow: Meditsina; 2018. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ejtahed H.S., Mardi P., Hejrani B., Mahdavi F.S., Ghoreshi B., Gohari K., et al. Association between junk food consumption and mental health problems in adults: a systematic review and meta-analysis. BMC Psychiatry. 2024; 24(1): 438. https://doi.org/10.1186/s12888-024-05889-8</mixed-citation><mixed-citation xml:lang="en">Ejtahed H.S., Mardi P., Hejrani B., Mahdavi F.S., Ghoreshi B., Gohari K., et al. Association between junk food consumption and mental health problems in adults: a systematic review and meta-analysis. BMC Psychiatry. 2024; 24(1): 438. https://doi.org/10.1186/s12888-024-05889-8</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Malmir H., Mahdavi F.S., Ejtahed H.S., Kazemian E., Chaharrahi A., Mohammadian Khonsari N., et al. Junk food consumption and psychological distress in children and adolescents: a systematic review and meta-analysis. Nutr. Neurosci. 2023; 26(9): 807–27. https://doi.org/10.1080/1028415X.2022.2094856</mixed-citation><mixed-citation xml:lang="en">Malmir H., Mahdavi F.S., Ejtahed H.S., Kazemian E., Chaharrahi A., Mohammadian Khonsari N., et al. Junk food consumption and psychological distress in children and adolescents: a systematic review and meta-analysis. Nutr. Neurosci. 2023; 26(9): 807–27. https://doi.org/10.1080/1028415X.2022.2094856</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Canbolat A.A., Lombardo M., Mondragon A.D.C., López J.M.M., Bechelany M., Karav S. Bovine colostrum in pediatric nutrition and health. Nutrients. 2024; 16(24): 4305. https://doi.org/10.3390/nu16244305</mixed-citation><mixed-citation xml:lang="en">Canbolat A.A., Lombardo M., Mondragon A.D.C., López J.M.M., Bechelany M., Karav S. Bovine colostrum in pediatric nutrition and health. Nutrients. 2024; 16(24): 4305. https://doi.org/10.3390/nu16244305</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J., Deng H., Bai J., Zhou X., Zhao Y., Zhu Y., et al. Health-promoting properties of barley: A review of nutrient and nutraceutical composition, functionality, bioprocessing, and health benefits. Crit. Rev. Food Sci. Nutr. 2023; 63(9): 1155–69. https://doi.org/10.1080/10408398.2021.1972926</mixed-citation><mixed-citation xml:lang="en">Zhang J., Deng H., Bai J., Zhou X., Zhao Y., Zhu Y., et al. Health-promoting properties of barley: A review of nutrient and nutraceutical composition, functionality, bioprocessing, and health benefits. Crit. Rev. Food Sci. Nutr. 2023; 63(9): 1155–69. https://doi.org/10.1080/10408398.2021.1972926</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Davy J. On the colostrum of the cow. Med. Chir. Trans. 1845; 28: 83–94. https://doi.org/10.1177/095952874502800106</mixed-citation><mixed-citation xml:lang="en">Davy J. On the colostrum of the cow. Med. Chir. Trans. 1845; 28: 83–94. https://doi.org/10.1177/095952874502800106</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Crowther C., Raistrick H. A comparative study of the proteins of the colostrum and milk of the cow and their relations to serum proteins. Biochem. J. 1916; 10(3): 434–52. https://doi.org/10.1042/bj0100434</mixed-citation><mixed-citation xml:lang="en">Crowther C., Raistrick H. A comparative study of the proteins of the colostrum and milk of the cow and their relations to serum proteins. Biochem. J. 1916; 10(3): 434–52. https://doi.org/10.1042/bj0100434</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Moore D.A., Taylor J., Hartman M.L., Sischo W.M. Quality assessments of waste milk at a calf ranch. J. Dairy Sci. 2009; 92(7): 3503–9.</mixed-citation><mixed-citation xml:lang="en">Moore D.A., Taylor J., Hartman M.L., Sischo W.M. Quality assessments of waste milk at a calf ranch. J. Dairy Sci. 2009; 92(7): 3503–9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sienkiewicz M., Szymanska P., Fichna J. Supplementation of bovine colostrum in inflammatory bowel disease: benefits and contraindications. Adv. Nutr. 2021; 12(2): 533–45.</mixed-citation><mixed-citation xml:lang="en">Sienkiewicz M., Szymanska P., Fichna J. Supplementation of bovine colostrum in inflammatory bowel disease: benefits and contraindications. Adv. Nutr. 2021; 12(2): 533–45.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gomes R.D., Anaya K., Galdino A.B., Oliveira J.P., Gama M.A., Medeiros C.A., et al. H. Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders. NFS Journal. 2021; 25: 1–11.</mixed-citation><mixed-citation xml:lang="en">Gomes R.D., Anaya K., Galdino A.B., Oliveira J.P., Gama M.A., Medeiros C.A., et al. H. Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders. NFS Journal. 2021; 25: 1–11.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Родионов Г.В., Изилов Ю.С., Харитонов С.Н., Табакова Л.П. Скотоводство: учебник для студентов высших учебных заведений, обучающихся по специальности «Зоотехния». М.: КолосС; 2007.</mixed-citation><mixed-citation xml:lang="en">Rodionov G.V., Izilov Yu.S., Kharitonov S.N., Tabakova L.P. Cattle Breeding: Textbook for Higher Education Students Studying Zootechnics. Moscow: KolosS, 2007 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Сироткин В.И. Выращивание телят. Нормирование кормления: системы содержания. М.: Россельхозиздат; 1987.</mixed-citation><mixed-citation xml:lang="en">Sirotkin V.I. Calf Rearing. Feeding Rationing: Housing Systems [Vyrashchivanie telyat. Normirovanie kormleniya: sistemy soderzhaniya]. Moscow: Rosselkhozizdat; 1987. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Process for the preparation of colostrum. Patent USA № US6521277; 2003.</mixed-citation><mixed-citation xml:lang="en">Process for the preparation of colostrum. Patent USA № US6521277; 2003.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Davison G. Bovine colostrum and immune function after exercise. Med. Sport Sci. 2012; 59: 62–9. https://doi.org/10.1159/000341966</mixed-citation><mixed-citation xml:lang="en">Davison G. Bovine colostrum and immune function after exercise. Med. Sport Sci. 2012; 59: 62–9. https://doi.org/10.1159/000341966</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ulfman L.H., Leusen J.H.W., Savelkoul H.F.J., Warner J.O., van Neerven R.J.J. Effects of bovine immunoglobulins on immune function, allergy, and infection. Front. Nutr. 2018; 5: 52. https://doi.org/10.3389/fnut.2018.00052</mixed-citation><mixed-citation xml:lang="en">Ulfman L.H., Leusen J.H.W., Savelkoul H.F.J., Warner J.O., van Neerven R.J.J. Effects of bovine immunoglobulins on immune function, allergy, and infection. Front. Nutr. 2018; 5: 52. https://doi.org/10.3389/fnut.2018.00052</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gasser M., Lissner R., Nawalaniec K., Hsiao L.L., Waaga-Gasser A.M. KMP01D demonstrates beneficial anti-inflammatory effects on immune cells: an ex vivo preclinical study of patients with colorectal cancer. Front. Immunol. 2020; 11: 684. https://doi.org/10.3389/fimmu.2020.00684</mixed-citation><mixed-citation xml:lang="en">Gasser M., Lissner R., Nawalaniec K., Hsiao L.L., Waaga-Gasser A.M. KMP01D demonstrates beneficial anti-inflammatory effects on immune cells: an ex vivo preclinical study of patients with colorectal cancer. Front. Immunol. 2020; 11: 684. https://doi.org/10.3389/fimmu.2020.00684</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson R.C., Dalziel J.E., Haggarty N.W., Dunstan K.E., Gopal P.K., Roy N.C. Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers. J. Dairy Sci. 2019; 102(12): 10772–8. https://doi.org/10.3168/jds.2019-16951</mixed-citation><mixed-citation xml:lang="en">Anderson R.C., Dalziel J.E., Haggarty N.W., Dunstan K.E., Gopal P.K., Roy N.C. Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers. J. Dairy Sci. 2019; 102(12): 10772–8. https://doi.org/10.3168/jds.2019-16951</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hall J.A., Bobe G., Vorachek W.R., Estill C.T., Mosher W.D., Pirelli G.J., et al. Effect of supranutritional maternal and colostral selenium supplementation on passive absorption of immunoglobulin G in selenium-replete dairy calves. J. Dairy Sci. 2014; 97(7): 4379–91. https://doi.org/10.3168/jds.2013-7481</mixed-citation><mixed-citation xml:lang="en">Hall J.A., Bobe G., Vorachek W.R., Estill C.T., Mosher W.D., Pirelli G.J., et al. Effect of supranutritional maternal and colostral selenium supplementation on passive absorption of immunoglobulin G in selenium-replete dairy calves. J. Dairy Sci. 2014; 97(7): 4379–91. https://doi.org/10.3168/jds.2013-7481</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kamada H., Nonaka I., Ueda Y., Murai M. Selenium addition to colostrum increases immunoglobulin G absorption by newborn calves. J. Dairy Sci. 2007; 90(12): 5665–70. https://doi.org/10.3168/jds.2007-0348</mixed-citation><mixed-citation xml:lang="en">Kamada H., Nonaka I., Ueda Y., Murai M. Selenium addition to colostrum increases immunoglobulin G absorption by newborn calves. J. Dairy Sci. 2007; 90(12): 5665–70. https://doi.org/10.3168/jds.2007-0348</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Shini V.S., Udayarajan C.T., Nisha P. A comprehensive review on lactoferrin: a natural multifunctional glycoprotein. Food Funct. 2022; 13(23): 11954–72. https://doi.org/10.1039/d2fo02371g</mixed-citation><mixed-citation xml:lang="en">Shini V.S., Udayarajan C.T., Nisha P. A comprehensive review on lactoferrin: a natural multifunctional glycoprotein. Food Funct. 2022; 13(23): 11954–72. https://doi.org/10.1039/d2fo02371g</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Elzoghby A.O., Abdelmoneem M.A., Hassanin I.A., Abd Elwakil M.M., Elnaggar M.A., Mokhtar S., et al. Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier &amp; targeting ligand. Biomaterials. 2020; 263: 120355. https://doi.org/10.1016/j.biomaterials.2020.120355</mixed-citation><mixed-citation xml:lang="en">Elzoghby A.O., Abdelmoneem M.A., Hassanin I.A., Abd Elwakil M.M., Elnaggar M.A., Mokhtar S., et al. Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier &amp; targeting ligand. Biomaterials. 2020; 263: 120355. https://doi.org/10.1016/j.biomaterials.2020.120355</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vorland L.H. Lactoferrin: a multifunctional glycoprotein. APMIS. 1999; 107(11): 971–81. https://doi.org/10.1111/j.1699-0463.1999.tb01499.x</mixed-citation><mixed-citation xml:lang="en">Vorland L.H. Lactoferrin: a multifunctional glycoprotein. APMIS. 1999; 107(11): 971–81. https://doi.org/10.1111/j.1699-0463.1999.tb01499.x</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Baveye S., Elass E., Mazurier J., Spik G., Legrand D. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin. Chem. Lab. Med. 1999; 37(3): 281–6. https://doi.org/10.1515/CCLM.1999.049</mixed-citation><mixed-citation xml:lang="en">Baveye S., Elass E., Mazurier J., Spik G., Legrand D. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin. Chem. Lab. Med. 1999; 37(3): 281–6. https://doi.org/10.1515/CCLM.1999.049</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hirai Y., Kawakata N., Satoh K., Ikeda Y., Hisayasu S., Orimo H., et al. Concentrations of lactoferrin and iron in human milk at different stages of lactation. J. Nutr. Sci. Vitaminol. (Tokyo). 1990; 36(6): 531–44. https://doi.org/10.3177/jnsv.36.531</mixed-citation><mixed-citation xml:lang="en">Hirai Y., Kawakata N., Satoh K., Ikeda Y., Hisayasu S., Orimo H., et al. Concentrations of lactoferrin and iron in human milk at different stages of lactation. J. Nutr. Sci. Vitaminol. (Tokyo). 1990; 36(6): 531–44. https://doi.org/10.3177/jnsv.36.531</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Мамонтова Т.В., Айбазов А.М., Русакова О.С. Современные тенденции развития мирового и российского рынка биотехнологий в животноводстве. Сборник научных трудов Всероссийского научно-исследовательского института овцеводства и козоводства. 2014; 2(7): 292–300. https://elibrary.ru/tbisnz</mixed-citation><mixed-citation xml:lang="en">Mamontova T.V., Aibazov A.M., Rusakova O.S. Modern trends in the development of the global and Russian market of biotechnology in animal husbandry. Sbornik nauchnykh trudov Vserossiiskogo nauchno-issledovatel’skogo instituta ovtsevodstva i kozovodstva. 2014; 2(7): 292–300. https://elibrary.ru/tbisnz (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">FDA GRAS Notification as GRN 000042. Generally Recognized as Safe Determination for Bovine Lactoferrin; 2001.</mixed-citation><mixed-citation xml:lang="en">FDA GRAS Notification as GRN 000042. Generally Recognized as Safe Determination for Bovine Lactoferrin; 2001.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Титов Е.И., Тихомирова Н.А., Ионова И.И. Выделение и изучение железосвязывающей способности лактоферрина коровьего молока. Вопросы питания. 2019; 88(1): 91–5. https://doi.org/10.24411/0042-8833-2019-10011 https://elibrary.ru/vvqqgf</mixed-citation><mixed-citation xml:lang="en">Titov E.I., Tikhomirova N.A., Ionova I.I. Investigation of the iron-binding capacity of the bovine lactoferrin. Voprosy pitaniya. 2019; 88(1): 91–5. https://doi.org/10.24411/0042-8833-2019-10011 https://elibrary.ru/vvqqgf (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьмин С.В., Сетко А.Г., Синицына О.О., Сутункова М.П., Майзель С.Г. Научно-методические подходы к биопрофилактике нарушений состояния здоровья детей и подростков, проживающих в условиях воздействия неблагоприятных климатогеографических факторов. Гигиена и санитария. 2024; 103(12): 1473–9. https://doi.org/10.47470/0016-9900-2024-103-12-1473-1479 https://elibrary.ru/ajfwcj</mixed-citation><mixed-citation xml:lang="en">Kuzmin S.V., Setko A.G., Sinitsyna O.O., Sutunkova M.P., Maisel S.G. Scientific and methodological approaches to the prevention of health disorders in children and adolescents living under the influence of adverse climatic and geographical factors. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2024; 103(12): 1473–9. https://doi.org/10.47470/0016-9900-2024-103-12-1473-1479 https://elibrary.ru/ajfwcj (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Buttar H.S., Bagwe S.M., Bhullar S.K., Kaur G. Health benefits of bovine colostrum in children and adults. In: Watson R.R., Collier R.J., Preedy V.R., eds. Dairy in Human Health and Disease Across the Lifespan. Academic Press; 2017: 3–20. https://doi.org/10.1016/B978-0-12-809868-4.00001-7</mixed-citation><mixed-citation xml:lang="en">Buttar H.S., Bagwe S.M., Bhullar S.K., Kaur G. Health benefits of bovine colostrum in children and adults. In: Watson R.R., Collier R.J., Preedy V.R., eds. Dairy in Human Health and Disease Across the Lifespan. Academic Press; 2017: 3–20. https://doi.org/10.1016/B978-0-12-809868-4.00001-7</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Stelwagen K., Carpenter E., Haigh B., Hodgkinson A., Wheeler T.T. Immune components of bovine colostrum and milk. J. Anim. Sci. 2009; 87(13 Suppl.): 3–9. https://doi.org/10.2527/jas.2008-1377</mixed-citation><mixed-citation xml:lang="en">Stelwagen K., Carpenter E., Haigh B., Hodgkinson A., Wheeler T.T. Immune components of bovine colostrum and milk. J. Anim. Sci. 2009; 87(13 Suppl.): 3–9. https://doi.org/10.2527/jas.2008-1377</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Новокшанова А.Л. Аллергия: насколько высок риск потребления молочных продуктов. Переработка молока. 2024; (8): 38–40. https://doi.org/10.33465/2222-5455-2024-8-38-40 https://elibrary.ru/avfhie</mixed-citation><mixed-citation xml:lang="en">Novokshanova, A.L. Allergies: how high is the risk of consuming dairy products. Pererabotka moloka. 2024; (8): 38–40. https://doi.org/10.33465/2222-5455-2024-8-38-40 https://elibrary.ru/avfhie (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Бурачевский Н.В., Донник И.М., Кузьмин С.В., Майзель С.Г., Осьмакова А.Г., Пастухов А.М. и др. Установка для получения бактериологически чистого протеинового продукта с повышенным содержанием минорных белков. Патент РФ № RU2736646C1; 2020. https://elibrary.ru/ceupgj</mixed-citation><mixed-citation xml:lang="en">Burachevskii N.V., Donnik I.M., Kuz’min S.V., Maizel S.G., Osmakova A.G., Pastukhov A.M., et al. An installation for producing a bacteriologically pure protein product with a high content of minor proteins. Patent RF N RU2736646C1; 2020. https://elibrary.ru/ceupgj (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Сетко А.Г., Юскина О.Н. Особенности проведения санитарно-эпидемиологической экспертизы при государственной регистрации биологически активных добавок к пище на основе пробиотических микроорганизмов. Вопросы питания. 2024; 93(3): 93. https://elibrary.ru/crmzxn</mixed-citation><mixed-citation xml:lang="en">Setko A.G., Yuskina O.N. Features of conducting sanitary and epidemiological examinations during state registration of dietary supplements based on probiotic microorganisms. Voprosy pitaniya. 2024; 93(3): 93. https://elibrary.ru/crmzxn (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Краснова И.С., Коробейникова Т.В. Разработка антиоксидантных композиций с синергетическим эффектом из коровьего молозива и витаминов. Известия высших учебных заведений. Пищевая технология. 2013; (1): 52–5. https://elibrary.ru/pzfneh</mixed-citation><mixed-citation xml:lang="en">Krasnova I.S., Korobeinikova T.V. Development of antioxidant compositions with a synergistic effect from cow colostrum and vitamins. Izvestiya vysshikh uchebnykh zavedenii. Pishchevaya tekhnologiya. 2013; (1): 52–5. https://elibrary.ru/pzfneh (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Головач Т.Н., Романович Р.В., Курченко В.П., Тарун Е.И. Антиоксидантный потенциал коровьего молозива, ферментированного ацидофильной палочкой. Пищевая промышленность. 2019; (4): 30–1. https://elibrary.ru/movphw</mixed-citation><mixed-citation xml:lang="en">Golovach T.N., Romanovich R.V., Kurchenko V.P., Tarun E.I. Antioxidant potential of bovine colostrum fermented with acidophilus bacillus. Pishchevaya promyshlennost’. 2019; (4): 30–1. https://elibrary.ru/movphw (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьмин С.В., Русаков В.Н., Синицына О.О., Майзель С.Г., Алешкин В.А. Молозиво коров: компонентный состав, биологические свойства и практика применения. Вопросы питания. 2023; 92(2): 97–108. https://doi.org/10.33029/0042-8833-2023-92-2-97-108 https://elibrary.ru/igzpcv</mixed-citation><mixed-citation xml:lang="en">Kuzmin S.V., Rusakov V.N., Sinitsyna O.O., Myzel S.G., Aleshkin V.A. Cow colostrum: component composition, biological properties and application practice. Voprosy pitaniya. 2023; 92(2): 97–108. https://doi.org/10.33029/0042-8833-2023-92-2-97-108 https://elibrary.ru/igzpcv (in Russian)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
