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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2025-104-12-1700-1705</article-id><article-id custom-type="edn" pub-id-type="custom">ovbcey</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-5344</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНА ТРУДА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OCCUPATIONAL HEALTH</subject></subj-group></article-categories><title-group><article-title>Клинико-функциональные показатели пациентов с профессиональной хронической обструктивной болезнью лёгких в постковидном периоде</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and functional parameters in patients with occupational chronic obstructive pulmonary disease in the postcovid period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5180-8327</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мараев</surname><given-names>Максим Дмитриевич</given-names></name><name name-style="western" xml:lang="en"><surname>Maraev</surname><given-names>Maksim D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аспирант ФГБНУ ВСИМЭИ, 665827, Ангарск, Россия</p><p>e-mail: maraev-98@mail.ru</p></bio><bio xml:lang="en"><p>Postgraduate student East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation</p><p>e-mail: maraev-98@mail.ru</p></bio><email xlink:type="simple">maraev-98@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9072-2781</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катаманова</surname><given-names>Елена Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Katamanova</surname><given-names>Elena V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, главный врач клиники ФГБНУ ВСИМЭИ, 665827, Ангарск, Россия</p><p>e-mail: katamanova_e_v@mail.ru</p></bio><bio xml:lang="en"><p>DSc (Medicine), Professor, Chief Physician, East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation; Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, 664049, Russian Federation</p><p>e-mail: katamanova_e_v@mail.ru</p></bio><email xlink:type="simple">katamanova_e_v@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1434-1853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бейгель</surname><given-names>Елена Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Beygel</surname><given-names>Elena A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. мед. наук, доцент, зам. главного врача по медицинской части, врач аллерголог-иммунолог клиники ФГБНУ ВСИМЭИ, 665827, Ангарск, Россия</p><p>e-mail: elena-abramatec@rambler.ru</p></bio><bio xml:lang="en"><p>PhD, (Medicine), deputy Chief Physician, allergologist-immunologist, East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation; Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, 664049, Russian Federation</p><p>e-mail: elena-abramatec@rambler.ru</p></bio><email xlink:type="simple">elena-abramatec@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Восточно-Сибирский институт медико-экологических исследований»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>East-Siberian Institute of Medical and Ecological Research</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Восточно-Сибирский институт медико-экологических исследований»; Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>East-Siberian Institute of Medical and Ecological Research; Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2026</year></pub-date><volume>104</volume><issue>12</issue><fpage>1700</fpage><lpage>1705</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мараев М.Д., Катаманова Е.В., Бейгель Е.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Мараев М.Д., Катаманова Е.В., Бейгель Е.А.</copyright-holder><copyright-holder xml:lang="en">Maraev M.D., Katamanova E.V., Beygel E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/5344">https://www.rjhas.ru/jour/article/view/5344</self-uri><abstract><sec><title>Введение</title><p>Введение. Профессиональная хроническая обструктивная болезнь лёгких (ПХОБЛ) – одна из распространённых причин утраты трудоспособности. Инфекция SARS-CoV-2 вызвала новую проблему: сочетание ПХОБЛ и постковидного синдрома приводит к утяжелению течения болезни, что требует своевременного выявления маркёров нарушений у таких пациентов с последующей разработкой персонализированных методов лечения и реабилитации.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проанализированы клинико-функциональные показатели 90 мужчин с хронической обструктивной болезнью лёгких (ХОБЛ) профессионального и непрофессионального генеза: 30 человек с ПХОБЛ и перенесённым COVID-19, 30 человек с ПХОБЛ без COVID-19 и 30 человек с непрофессиональной ХОБЛ и COVID-19. Оценивали одышку (шкалы Борга, mMRC, CAT), спирометрию (ФЖЕЛ, ОФВ1, ФЖЕЛ/ОФВ1) и качество жизни (SF-36). Сравнение трёх групп проводили с помощью теста Краскела – Уоллиса и метода Манна – Уитни при попарном сравнении.</p></sec><sec><title>Результаты</title><p>Результаты. По данным анкетирования установлено: баллы по шкале САТ в группе 1 выше, чем в группах 2 и 3 (p &lt; 0,017). Степень одышки по шкале mMRC в группе 1 значимо выше (p = 0,01), по шкале Борга до и после нагрузки баллы в группе 1 выше, чем в группе 3 (p &lt; 0,001), и выше, чем в группе 2 после нагрузки (p = 0,006). Спирометрические показатели ОФВ1 и ОФВ1/ФЖЕЛ в группе 1 хуже, чем в группе 2 и 3 (p &lt; 0,001 и p = 0,001; p = 0,016 и p = 0,007 соответственно). Физический и психический компоненты качества жизни по опроснику SF-36 в группе 1 ниже, чем в группе 2 (p = 0,014 и p = 0,003).</p></sec><sec><title>Ограничение исследования</title><p>Ограничение исследования. Имеются количественные ограничения, обусловленные полом обследованных лиц и дизайном исследования.</p></sec><sec><title>Заключение</title><p>Заключение. Исследование клинико-функциональных параметров пациентов с ХОБЛ профессионального и непрофессионального генеза показало, что у перенёсших COVID-19 симптомы выражены сильнее: кашель, мокрота, одышка, утомляемость, нарушения сна и дыхания, снижение физической активности. Также выше баллы по шкале Борга, что указывает на меньшую толерантность к нагрузкам.</p><p>Соблюдение этических стандартов. Исследование одобрено локальным этическим комитетом ФГБНУ «Восточно-Сибирский институт медико-экологических исследований» (протокол заседания № 2 от 21.02.2023 г.), проведено согласно общепринятым научным принципам Хельсинкской декларации Всемирной медицинской ассоциации (ред. 2013 г.). Все участники дали информированное добровольное письменное согласие на участие в исследовании.</p></sec><sec><title>Участие авторов</title><p>Участие авторов: Мараев М.Д. – концепция и дизайн исследования, сбор и обработка данных, написание текста и его редактирование; Катаманова Е.В. – написание текста, редактирование; Бейгель Е.А. – написание текста, редактирование. Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех её частей.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Работа выполнена в рамках поисковых научных исследований (ПНИ) «Разработка подходов к лечению и медицинской реабилитации пациентов при коморбидном течении постковидного синдрома и военнослужащих, пострадавших в боевых действиях» (рег. № 123032000011-5).</p></sec><sec><title>Поступила</title><p>Поступила: 06.11.2025 / Поступила после доработки: 18.11.2025 / Принята к печати: 02.12.2025 / Опубликована: 15.01.2026</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Occupational chronic obstructive pulmonary disease (OCOPD) is a serious cause of disability. The SARS-CoV-2 infection has caused a new problem: a combination of OCOPD and postcovid syndrome. The task of an occupational pathologist is to identify markers of disorders in such patients and develop personalized methods of treatment and rehabilitation.</p></sec><sec><title>Material and methods</title><p>Material and methods. The clinical and functional parameters in ninety men with chronic obstructive pulmonary disease (COPD) of occupational and non-occupational origin were analyzed: 30 OCOPD men with COVID-19, 30 OCOPD men without COVID-19, and 30 men with non-occupational COPD and COVID-19. Dyspnea (Borg scales, mMRC, CAT), spirometry (FVC, FEV1, FVC/FEV1) and quality of life (SF-36) were assessed. The three groups were compared using the Kraskel–Wallis test and the Mann–Whitney method in a pairwise comparison.</p></sec><sec><title>Results</title><p>Results. The CAT scores in group 1 are higher than in groups 2 and 3 (p&lt;0.017). The degree of dyspnea on the mMRC scale in group 1 was significantly higher (p=0.01). On the Borg scale, scores in group 1 before and after exercise were higher than in group 3 (p&lt;0.001) and group 2 after exercise (p=0.006). The FEV1 and FEV1/FVC spirometry indices in group 1 are worse than in group 2 and 3 (p&lt;0.001 and p=0.001; p=0.016 and p=0.007, respectively). The physical and mental components of the SF-36 quality of life in group 1 are lower than in group 2 (p=0.014 and p=0.003).</p></sec><sec><title>Limitations</title><p>Limitations. There are quantitative limitations due to the gender of the surveyed and the design of the study.</p></sec><sec><title>Conclusion</title><p>Conclusion. A study of the clinical and functional parameters in patients with occupational and non-occupational COPD has shown that those who have suffered from COVID-19 have more pronounced symptoms: cough, sputum, shortness of breath, fatigue, sleep and breathing disorders, decreased physical activity. They also score higher on the Borg scale, which indicates to a lower stress tolerance.</p><p>Compliance with ethical standards. The study was approved by the local Ethics Committee of the East Siberian Institute of Medical and Ecological Research (Minutes of meeting No. 2 dated 02/21/2023), conducted in accordance with the generally accepted scientific principles of the Helsinki Declaration of the World Medical Association (ed. 2013). All participants gave informed voluntary written consent to participate in the study.</p></sec><sec><title>Contribution</title><p>Contribution: Maraev M.D. – research concept and design, data collection and processing, text writing and editing; Katamanova E.V. – writing, editing; Beygel E.A. – writing, editing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Funding</title><p>Funding. The research was carried out within the framework of exploratory scientific research “Development of approaches to the treatment and medical rehabilitation of patients with comorbid postcovid syndrome and military personnel injured in combat” (Reg. №. 123032000011–5).</p></sec><sec><title>Received</title><p>Received: November 6, 2025 / Revised: November 18, 2025 / Accepted: December 2, 2025 / Published: January 15, 2026</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>профессиональная хроническая обструктивная болезнь лёгких</kwd><kwd>постковидный период</kwd><kwd>диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>occupational chronic obstructive pulmonary disease</kwd><kwd>postcovid period</kwd><kwd>diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шпагина Л.А., Котова О.С., Шпагин И.С., Кузнецова Г.В., Камнева Н.В. 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