Introduction. Growing progress in scientific research into the impact of water pollution on public water supplies has necessitated continuous improvement in the methodology for developing standard values for new influencing factors and water use conditions, an assessment of which is the subject of this publication.

Materials and Methods. The study’s materials included publications and the results of own research on the hygienic regulation of chemicals in water bodies used for domestic and drinking water, the hygienic aspects of seawater desalination and the preparation of drinking water, as well as regulatory and methodological documents in the field of water hygiene.

Results. The article presents such main scientific achievements in the field of drinking water hygiene as development of coefficients of species-specific differences in laboratory animal health parameters during extrapolation of experimental data to humans, modern histomorphological, biochemical, and genetic methods and various functional loads on experimental animal bodies during toxicological studies, additional criteria for assessing drinking water quality, a six-stage scheme for standardizing essential elements, new biophysical indicators of drinking water quality, hygienic requirements for local systems of additional purification and disinfection of drinking water. Innovative proposals for the scientific substantiation of hygienic requirements for water with a limited purpose of use – domestic and domestic – are outlined, as well as an algorithm for taking into account the proportional contribution of uncertainty factors of its chemical composition in the hygienic assessment of the chemical safety of drinking water quality.

Limitations. The study is limited to the characteristics of water used for domestic and drinking water and domestic water use.

Conclusion. An analysis of the achievements of scientific research on the hygienic standardization of drinking water quality demonstrated its high effectiveness and determined the feasibility of further promising research in this area outlined in the article.

Compliance with ethical standards. This study does not require the approval of a biomedical ethics committee.

Contribution: Rakhmanin Yu.A. – study concept and design, writing, editing; Sinitsyna O.O. – material collection and data processing, writing, editing; Egorova N.A. – material collection and data processing, illustrations; Turbinsky V.V. – material preparation and data processing; Alekseeva A.V., Ryzhova I.N. – material collection and data processing;Kuz N.V. – material collection and illustration; Kochetkova M.G. – illustration. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: December 10, 2025 / Revised: December 16, 2025 / Accepted: December 2, 2025 / Published: February 10, 2026