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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2020-99-8-861-865</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-54</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОЦЕНКА РИСКОВ ДЛЯ ЗДОРОВЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEALTH RISK ASSESSMENT</subject></subj-group></article-categories><title-group><article-title>Оценка риска развития заболеваний системы кровообращения среди взрослого населения Пермского края в условиях химического загрязнения атмосферного воздуха</article-title><trans-title-group xml:lang="en"><trans-title>Assessing risks of circulatory disorders among adults exposed to ambient air chemical contamination when living in the perm region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1548-228X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Четверкина</surname><given-names>Кристина Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Chetverkina</surname><given-names>Kristina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ст. науч. сотр. отдела анализа риска для здоровья ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Россия, 614045, Пермь.</p><p>e-mail: chetverkina@fcrisk.ru</p></bio><bio xml:lang="en"><p>MD, Senior Researcher of the Health Risk Analysis Department, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation.</p><p>e-mail: chetverkina@fcrisk.ru</p></bio><email xlink:type="simple">chetverkina@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Scientific Center for Medical and Preventive Health Risk Management Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>09</month><year>2020</year></pub-date><volume>99</volume><issue>8</issue><fpage>861</fpage><lpage>865</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Четверкина К.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Четверкина К.В.</copyright-holder><copyright-holder xml:lang="en">Chetverkina K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/54">https://www.rjhas.ru/jour/article/view/54</self-uri><abstract><sec><title>Введение</title><p>Введение. Актуальность изучения заболеваний системы кровообращения обусловлена тем, что представленный класс болезней составляет наибольшую долю в структуре причин смертности населения России (около 55%). При этом экологическая обусловленность заболевания вносит не менее значимый вклад в формирование заболеваемости. Выявление химических веществ, оказывающих влияние на развитие патологии со стороны системы кровообращения, и последующее воздействие на них может способствовать снижению уровня заболеваемости и смертности населения по изучаемому классу болезней.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В качестве исходных материалов использованы данные о химическом загрязнении атмосферного воздуха и данные о первичной заболеваемости взрослого населения по классу «болезни системы кровообращения», проживающего на территории Пермского края в период с 2013 по 2017 г., которые обработаны с применением ряда методов, включающих в себя гигиенические исследования, оценку риска здоровью населения при условии хронической ингаляционной экспозиции, методы математического моделирования в системе «здоровье - окружающая среда».</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что на территории Пермского края отмечается тенденция к росту первичной заболеваемости взрослого населения в отношении заболеваний системы кровообращения. На фоне установленного превышения ПДКс.с. для фенола до 6,67 раза и бензола до 2,73 раза установлены недопустимые уровни риска, связанные с развитием сердечно-сосудистых заболеваний (HI до 1,90), наибольший вклад в формирование которого вносят фенол (до 78,52%) и бензол (до 75,59%). Результаты математического моделирования позволили установить достоверную, адекватную причинно-следственную связь первичной заболеваемости взрослого населения болезнями системы кровообращения с уровнем загрязнения атмосферного воздуха фенолом.</p></sec><sec><title>Заключение</title><p>Заключение. Установлены превышения содержания фенола и бензола в атмосферном воздухе. Идентифицирована и параметризирована достоверная причинно-следственная связь между загрязнением атмосферного воздуха фенолом и формированием болезней системы кровообращения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. It is vital to study circulatory diseases as they account for the greatest share in causes of death in Russia (about 55%). Also, environmental factors contribute significantly to morbidity with circulatory diseases. It is important to reveal chemicals that exert their impacts on pathology occurrence in the circulatory system; should such impacts be eliminated or reduced, it will make for a decrease in morbidity and mortality among the population caused by the nosologies being considered in the present work.</p></sec><sec><title>Material and methods</title><p>Material and methods. We took data on chemical contamination of ambient air and data on primary morbidity as per the “diseases of the circulatory system” category among the adult population living in the Perm region over 2013-2017 as or initial data. All the data were processed with many techniques including hygienic examination, health risk assessment under chronic inhalation exposure, and mathematic modeling within the “health - environment” system.</p></sec><sec><title>Results</title><p>Results. Our research results allowed establishing that there was an ascending trend in primary morbidity with circulatory diseases among the population living in the Perm region. We revealed that phenol concentrations amounted up to 6.67 MPC average daily, and benzene ones, up to 2.37 MPC average daily; simultaneously, we revealed unacceptable risk regarding circulatory diseases (harm index (HI) was up to 1.9), and the greatest contribution into it was made by phenol (up to 78.52%) and benzene (up to 75.59%). Mathematic modeling allowed establishing there was an authentic and relevant cause-and-effect relation between primary morbidity with circulatory diseases among the adult population and ambient air contamination with phenol.</p></sec><sec><title>Conclusions</title><p>Conclusions. We revealed phenol and benzene concentrations in ambient air which were significantly higher than MPC; identified and parameterized an authentic cause-and-effect relation between ambient air contamination with phenol and circulatory diseases.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистая система</kwd><kwd>взрослое население</kwd><kwd>заболевания системы кровообращения</kwd><kwd>фенол</kwd><kwd>риск здоровью</kwd><kwd>Пермский край</kwd><kwd>математическое моделирование</kwd><kwd>атмосферный воздух</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular system</kwd><kwd>adult population</kwd><kwd>circulatory diseases</kwd><kwd>phenol</kwd><kwd>health risk</kwd><kwd>Perm region</kwd><kwd>mathematic modeling</kwd><kwd>ambient air</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Попова А.Ю., Зайцева Н.В., Май И.В. 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