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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medlit</journal-id><journal-title-group><journal-title xml:lang="ru">Гигиена и санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Hygiene and Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0016-9900</issn><issn pub-type="epub">2412-0650</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0016-9900-2018-97-8-710-713</article-id><article-id custom-type="elpub" pub-id-type="custom">medlit-616</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИГИЕНА ОКРУЖАЮЩЕЙ СРЕДЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENVIRONMENTAL HYGIENE</subject></subj-group></article-categories><title-group><article-title>Гигиенические аспекты эндои экзогенных методов профилактики кариеса и их эффективность в реминерализации эмали зубов</article-title><trans-title-group xml:lang="en"><trans-title>Hygienic aspects of endo- and exogenic methods of prevention of caries and their efficiency in the remineralization of teeth enamel</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9922-137X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ипполитов</surname><given-names>Юрий Алексеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Ippolitov</surname><given-names>Yuriy A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, зав. кафедрой детской стоматологии с ортодонтией ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко».</p><p>e-mail: dsvgma@mail.ru</p></bio><bio xml:lang="en"><p>Doctor of medical sciences, head of the department of pediatric dentistry and orthodontics of the N.N. Burdenko Voronezh State Medical University, Voronezh, 394036, Russian Federation.</p><p>e-mail: dsvgma@mail.ru</p></bio><email xlink:type="simple">dsvgma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8610-1595</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотникова</surname><given-names>Я. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikova</surname><given-names>Ya. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6724-0063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Середин</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Seredin</surname><given-names>P. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1400-2870</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голощапов</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Goloshchapov</surname><given-names>D. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3330-6009</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беркович</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Berkovich</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко»</institution></aff><aff xml:lang="en"><institution>N.N. Burdenko Voronezh State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»</institution></aff><aff xml:lang="en"><institution>Voronezh State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2020</year></pub-date><volume>97</volume><issue>8</issue><fpage>710</fpage><lpage>713</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ипполитов Ю.А., Плотникова Я.А., Середин П.В., Голощапов Д.Л., Беркович М.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ипполитов Ю.А., Плотникова Я.А., Середин П.В., Голощапов Д.Л., Беркович М.В.</copyright-holder><copyright-holder xml:lang="en">Ippolitov Y.A., Plotnikova Y.A., Seredin P.V., Goloshchapov D.L., Berkovich M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rjhas.ru/jour/article/view/616">https://www.rjhas.ru/jour/article/view/616</self-uri><abstract><sec><title>Введение</title><p>Введение. По данным стоматологического обследования распространённость кариеса у взрослых в возрасте 33-45 лет составляет 98%. Исследования эффективности профилактики кариеса, проводимой с помощью чистки зубов, показали действенность данного направления. Но восстановление баланса между процессами деминерализации и реминерализации эмали экзогенные методы не гарантируют. Деминерализующие факторы будут преобладать в случае, если концентрация в смешанной слюне необходимых минеральных веществ будет снижена. Поэтому необходимо развитие эндогенных методик, которые будут способствовать процессу реминерализации эмали и нормализации ионно-молекулярного баланса.</p><p>Цель исследования — сравнить эндогенные или экзогенные методы в целях насыщения смешанной слюны минеральными комплексами в профилактике развития первичной деминерализации твёрдой ткани зуба.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. У 27 пациентов проанализирован химический состав осадка смешанной слюны методом ИК-спектроскопии. Для записи измерения ИК-спектров использовали спектрометр Verteх-70 (Bruker, Германия) и приставку нарушенного полного внутреннего отражения PLATINUMATR с алмазной призмой, а также проводили клиническое определение скорости реминерализации эмали (КОСРЭ-тест).</p></sec><sec><title>Результаты</title><p>Результаты. Обнаружена взаимосвязь между использованием эндо- и экзогенных методов насыщения смешанной слюны минеральными комплексами и изменениями, происходящими в её молекулярном составе, в пользу эффективности эндогенных методов.</p></sec><sec><title>Выводы</title><p>Выводы. Мы можем констатировать, что экзогенные методы профилактики дают недолгосрочный эффект поддержания баланса необходимого для реминерализации в смешанной слюне, в то врем, как эндогенные методы профилактики приводят к долгосрочному присутствию в смешанной слюне необходимых для реминерализации групп и комплексов. Жевательные таблетки с минеральным комплексом дают более выраженный эффект по сравнению с зубной пастой, содержащей мультиминеральный комплекс (р ≤ 0,05).</p></sec></abstract><trans-abstract xml:lang="en"><p>According to the dental survey, the prevalence of caries in 33-45 years aged adults amounts to 98%. Studies of the effectiveness of prevention of tooth decay have shown the effectiveness of this direction. But the exogenous methods do not guarantee the restoration of the balance between the processes of demineralization and remineralization of the enamel. Demineralizing factors will prevail if the concentration of essential minerals in the mixed saliva is reduced. Therefore, it is necessary to develop endogenous techniques that will promote the process of remineralization of enamel and normalization of the ion-molecular balance.</p><p>The aim of the study was to compare endogenous or exogenous methods in order to saturate mixed saliva with mineral complexes in preventing the development of primary demineralization of hard tooth tissue. Material and methods. The chemical composition of the mixed saliva sediment in 27 patients was analyzed by IR spectroscopy. To record the measurement of IR spectra, a Vertex-70 spectrometer (Bruker, Germany) and a PLATINUMATR full internal reflectance attachment with a diamond prism were used, as well as a clinical determination of the enamel remineralization rate (COSRE test) was performed.</p><p>Results and Discussion. The relationship between the use of endogenous and exogenous methods of saturation of mixed saliva with mineral complexes and changes occurring in its molecular composition has been revealed, in favor of the effectiveness of endogenous methods.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>смешанная слюна</kwd><kwd>ИК-спектры</kwd><kwd>глицерофосфат кальция</kwd><kwd>деминерализация</kwd><kwd>реминерализация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mixed saliva</kwd><kwd>IR spectra</kwd><kwd>calcium glycerophosphate</kwd><kwd>demineralization</kwd><kwd>remineralization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ипполитов Ю.А. Разработка и оценка эффективности методов нормализации обменных процессов твердой ткани зуба в условиях развития кариозного процесса. Автореф. дис. …д-ра мед. Наук. Воронеж; 2012. Доступно по: http://www.dissercat.com/content/razrabotka-i-otsenka-effektivnosti-metodov-normalizatsii-obmennykh-protsessov-tverdykh-tkane</mixed-citation><mixed-citation xml:lang="en">Ippolitov Yu.A. Development and evaluation of methods for normalization of metabolic process hard tooth tissue under caries process. [dissertation]. Voronezh MedicalState Academy; 2012. http://www.dissercat.com/content/razrabotka-i-otsenka-effektivnosti-metodov-normalizatsiiobmennykh-protsessov-tverdykh-tkane</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ньюман И.М. Минеральный обмен кости: пер. с англ. И.М. Ньюман. М. Медицина, 1961. 368 с.</mixed-citation><mixed-citation xml:lang="en">N’yuman I.M. Mineral’nyj obmen kosti: translation from English. I.M. N’yuman. M. Medicina, 1961. 368 p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">West N.X., Joiner A. Enamel mineral loss. J Dent. 2014;42: S2-S11. https://doi.org/10.1016/S0300-5712(14)50002-4</mixed-citation><mixed-citation xml:lang="en">West N.X., Joiner A. Enamel mineral loss. J Dent. 2014;42: S2-S11. https://doi.org/10.1016/S0300-5712(14)50002-4</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kutsch V.K. Dental caries: An updated medical model of risk assessment. J Prosthet Dent. 2014;111: 280-285. https://doi.org/10.1016/j.prosdent.2013.07.014</mixed-citation><mixed-citation xml:lang="en">Kutsch V.K. Dental caries: An updated medical model of risk assessment. J Prosthet Dent. 2014;111: 280-285. https://doi.org/10.1016/j.prosdent.2013.07.014</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pretty I.A., Ellwood R.P. The caries continuum: Opportunities to detect, treat and monitor the re-mineralization of early caries lesions. J Dent. 2013; 41, Supplement 2: S12-S21. https://doi.org/10.1016/j.jdent.2010.04.003</mixed-citation><mixed-citation xml:lang="en">Pretty I.A., Ellwood R.P. The caries continuum: Opportunities to detect, treat and monitor the re-mineralization of early caries lesions. J Dent. 2013; 41, Supplement 2: S12-S21. https://doi.org/10.1016/j.jdent.2010.04.003</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shellis R.P., Featherstone J.D.B., Lussi A. Understanding the chemistry of dental erosion. Monogr Oral Sci. 2014;25: 163-79. https://doi.org/10.1159/000359943</mixed-citation><mixed-citation xml:lang="en">Shellis R.P., Featherstone J.D.B., Lussi A. Understanding the chemistry of dental erosion. Monogr Oral Sci. 2014;25: 163-79. https://doi.org/10.1159/000359943</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Seredin P., Goloshchapov D., Prutskij T., Ippolitov Y. Phase Transformations in a Human Tooth Tissue at the Initial Stage of Caries. PLoS ONE. 2015;10: e0124008. https://doi.org/10.1371/journal.pone.0124008</mixed-citation><mixed-citation xml:lang="en">Seredin P., Goloshchapov D., Prutskij T., Ippolitov Y. Phase Transformations in a Human Tooth Tissue at the Initial Stage of Caries. PLoS ONE. 2015;10: e0124008. https://doi.org/10.1371/journal.pone.0124008</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shimada Y., Sadr A., Sumi Y., Tagami J. Application of Optical Coherence Tomography (OCT) for Diagnosis of Caries, Cracks, and Defects of Restorations. Curr Oral Health Rep. 2015;2: 73-80. https://doi.org/10.1007/s40496-015-0045-z</mixed-citation><mixed-citation xml:lang="en">Shimada Y., Sadr A., Sumi Y., Tagami J. Application of Optical Coherence Tomography (OCT) for Diagnosis of Caries, Cracks, and Defects of Restorations. Curr Oral Health Rep. 2015;2: 73-80. https://doi.org/10.1007/s40496-015-0045-z</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Karlsson L. Caries Detection Methods Based on Changes in Optical Properties between Healthy and Carious Tissue. Int J. Dent. 2010;2010: e270729. https://doi.org/10.1155/2010/270729</mixed-citation><mixed-citation xml:lang="en">Karlsson L. Caries Detection Methods Based on Changes in Optical Properties between Healthy and Carious Tissue. Int J. Dent. 2010;2010: e270729. https://doi.org/10.1155/2010/270729</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Featherstone J.D.B. The scince and practice of caries prevention. J Am Dent Assoc. 2000;131: 887-99. https://doi.org/10.14219/jada.archive.2000.0307</mixed-citation><mixed-citation xml:lang="en">Featherstone J.D.B. The scince and practice of caries prevention. J Am Dent Assoc. 2000;131: 887-99. https://doi.org/10.14219/jada.archive.2000.0307</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Magalhães A.C., Wiegand A., Rios D., Honório H.M., Buzalaf M.A.R. Insights into preventive measures for dental erosion. J Appl Oral Sci. 2009; 17: 75-86. https://doi.org/10.1590/S1678-77572009000200002</mixed-citation><mixed-citation xml:lang="en">Magalhães A.C., Wiegand A., Rios D., Honório H.M., Buzalaf M.A.R. Insights into preventive measures for dental erosion. J Appl Oral Sci. 2009; 17: 75-86. https://doi.org/10.1590/S1678-77572009000200002</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Featherstone J.D.B. The Continuum of Dental Caries-Evidence for a Dynamic Disease Process. J. Dent. Res. 2004;83: C39-C42. https://doi.org/10.1177/154405910408301S08</mixed-citation><mixed-citation xml:lang="en">Featherstone J.D.B. The Continuum of Dental Caries-Evidence for a Dynamic Disease Process. J. Dent. Res. 2004;83: C39-C42. https://doi.org/10.1177/154405910408301S08</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lippert F., Parker D.M., Jandt K.D. In vitro demineralization/remineralization cycles at human tooth enamel surfaces investigated by AFM and nanoindentation. J Colloid Interface Sci. 2004;280: 442-8. https://doi.org/10.1016/j.jcis.2004.08.016</mixed-citation><mixed-citation xml:lang="en">Lippert F., Parker D.M., Jandt K.D. In vitro demineralization/remineralization cycles at human tooth enamel surfaces investigated by AFM and nanoindentation. J Colloid Interface Sci. 2004;280: 442-8. https://doi.org/10.1016/j.jcis.2004.08.016</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jefferies S.R. Advances in remineralization for early carious lesions: a comprehensive review. Compend Contin Educ Dent Jamesburg NJ 1995. 2014;35: 237-43; quiz 244.</mixed-citation><mixed-citation xml:lang="en">Jefferies S.R. Advances in remineralization for early carious lesions: a comprehensive review. Compend Contin Educ Dent Jamesburg NJ 1995. 2014;35: 237-43; quiz 244.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Memarpour M., Soltanimehr E., Sattarahmady N. Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion. Microsc Res Tech. 2015; https://doi.org/10.1002/jemt.22543</mixed-citation><mixed-citation xml:lang="en">Memarpour M., Soltanimehr E., Sattarahmady N. Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion. Microsc Res Tech. 2015; https://doi.org/10.1002/jemt.22543</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rirattanapong P., Vongsavan K., Tepvichaisillapakul M. Effect of five different dental products on surface hardness of enamel exposed to chlorinated water in vitro. Southeast Asian J Trop Med Public Health. 2011; 42: 1293-8.</mixed-citation><mixed-citation xml:lang="en">Rirattanapong P., Vongsavan K., Tepvichaisillapakul M. Effect of five different dental products on surface hardness of enamel exposed to chlorinated water in vitro. Southeast Asian J Trop Med Public Health. 2011; 42: 1293-8.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Carvalho F.G., Oliveira B.F., Carlo H.L., Santos R.L., Guenês G.M.T., Castro R.D. Effect of Remineralizing Agents on the Prevention of Enamel Erosion: A Systematic ReviewEffect of Remineralizing Agents on the Prevention of Enamel Erosion: A Systematic Review. Braz Res Pediatr Dent IntegrClin. 2014; 14: 55-64.</mixed-citation><mixed-citation xml:lang="en">Carvalho F.G., Oliveira B.F., Carlo H.L., Santos R.L., Guenês G.M.T., Castro R.D. Effect of Remineralizing Agents on the Prevention of Enamel Erosion: A Systematic ReviewEffect of Remineralizing Agents on the Prevention of Enamel Erosion: A Systematic Review. Braz Res Pediatr Dent IntegrClin. 2014; 14: 55-64.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sathe N., ChakradharRaju R.V.S., Chandrasekhar V. Effect of three different remineralizing agents on enamel caries formation-an in vitro study. Kathmandu Univ Med J KUMJ. 2014;12: 16-20.</mixed-citation><mixed-citation xml:lang="en">Sathe N., ChakradharRaju R.V.S., Chandrasekhar V. Effect of three different remineralizing agents on enamel caries formation-an in vitro study. Kathmandu Univ Med J KUMJ. 2014;12: 16-20.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Danelon M., Pessan J.P., Neto F.N.S., de Camargo E.R., Delbem A.C.B. Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study. J Dent. 2015; 43: 806-13. https://doi.org/10.1016/j.jdent.2015.04.010</mixed-citation><mixed-citation xml:lang="en">Danelon M., Pessan J.P., Neto F.N.S., de Camargo E.R., Delbem A.C.B. Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study. J Dent. 2015; 43: 806-13. https://doi.org/10.1016/j.jdent.2015.04.010</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Chen H.-P., Chang C.-H., Liu J.-K., Chuang S.-F., Yang J.-Y. Effect of fluoride containing bleaching agents on enamel surface properties. J Dent. 2008; 36: 718-25. https://doi.org/10.1016/j.jdent.2008.05.003</mixed-citation><mixed-citation xml:lang="en">Chen H.-P., Chang C.-H., Liu J.-K., Chuang S.-F., Yang J.-Y. Effect of fluoride containing bleaching agents on enamel surface properties. J Dent. 2008; 36: 718-25. https://doi.org/10.1016/j.jdent.2008.05.003</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang M., He L.B., Exterkate R.M., Cheng L., Li J.Y., Cate J.M. Ten et al. Biofilm layers affect the treatment outcomes of NaF and Nano-hydroxyapatite. J Dent Res. 2015; 94: 602-7. https://doi.org/10.1177/0022034514565644</mixed-citation><mixed-citation xml:lang="en">Zhang M., He L.B., Exterkate R.M., Cheng L., Li J.Y., Cate J.M. Ten et al. Biofilm layers affect the treatment outcomes of NaF and Nano-hydroxyapatite. J Dent Res. 2015; 94: 602-7. https://doi.org/10.1177/0022034514565644</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">García-Godoy F., Hicks M.J. Maintaining the integrity of the enamel surface: The role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization. J Am Dent Assoc. 2008; 139, Supplement 2: 25S-34S. https://doi.org/10.14219/jada.archive.2008.0352</mixed-citation><mixed-citation xml:lang="en">García-Godoy F., Hicks M.J. Maintaining the integrity of the enamel surface: The role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization. J Am Dent Assoc. 2008; 139, Supplement 2: 25S-34S. https://doi.org/10.14219/jada.archive.2008.0352</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hara A.T., Zero D.T. The potential of saliva in protecting against dental erosion. Monogr Oral Sci. 2014;25: 197-205. https://doi.org/10.1159/000360372</mixed-citation><mixed-citation xml:lang="en">Hara A.T., Zero D.T. The potential of saliva in protecting against dental erosion. Monogr Oral Sci. 2014;25: 197-205. https://doi.org/10.1159/000360372</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hara A.T., Zero D.T. The Caries Environment: Saliva, Pellicle, Diet, and Hard Tissue Ultrastructure. Dent Clin North Am. 2010;54: 455-67. https://doi.org/10.1016/j.cden.2010.03.008</mixed-citation><mixed-citation xml:lang="en">Hara A.T., Zero D.T. The Caries Environment: Saliva, Pellicle, Diet, and Hard Tissue Ultrastructure. Dent Clin North Am. 2010;54: 455-67. https://doi.org/10.1016/j.cden.2010.03.008</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Buzalaf M.A.R., Hannas A.R., Kato M.T. Saliva and dental erosion. J App lOral Sci Rev FOB.2012; 20: 493-502.</mixed-citation><mixed-citation xml:lang="en">Buzalaf M.A.R., Hannas A.R., Kato M.T. Saliva and dental erosion. J App lOral Sci Rev FOB.2012; 20: 493-502.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ihalin R., Loimaranta V., Tenovuo J. Origin, structure, and biological activities of peroxidases in human saliva. Arch Biochem Biophys. 2006; 445: 261-8. https://doi.org/10.1016/j.abb.2005.07.004.17</mixed-citation><mixed-citation xml:lang="en">Ihalin R., Loimaranta V., Tenovuo J. Origin, structure, and biological activities of peroxidases in human saliva. Arch Biochem Biophys. 2006; 445: 261-8. https://doi.org/10.1016/j.abb.2005.07.004.17</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigues L.M., Magrini T.D., Lima C.F., Scholz J., da Silva Martinho H., Almeida J.D. Effect of smoking cessation in saliva compounds by FTIR spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 2017; 174: 124-9. https://doi.org/10.1016/j.saa.2016.11.009</mixed-citation><mixed-citation xml:lang="en">Rodrigues L.M., Magrini T.D., Lima C.F., Scholz J., da Silva Martinho H., Almeida J.D. Effect of smoking cessation in saliva compounds by FTIR spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 2017; 174: 124-9. https://doi.org/10.1016/j.saa.2016.11.009</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Mikkonen J.J.W., Raittila J., Rieppo L., Lappalainen R., Kullaa A.M., Myllymaa S. Fourier Transform Infrared Spectroscopy and Photoacoustic Spectroscopy for Saliva Analysis. Appl Spectrosc 2016; 70: 1502-10. https://doi.org/10.1177/0003702816654149</mixed-citation><mixed-citation xml:lang="en">Mikkonen J.J.W., Raittila J., Rieppo L., Lappalainen R., Kullaa A.M., Myllymaa S. Fourier Transform Infrared Spectroscopy and Photoacoustic Spectroscopy for Saliva Analysis. Appl Spectrosc 2016; 70: 1502-10. https://doi.org/10.1177/0003702816654149</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hicks J., Garcia-Godoy F., Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent 2004; 28: 47-52. https://doi.org/10.17796/jcpd.28.1.yg6m443046k50u20</mixed-citation><mixed-citation xml:lang="en">Hicks J., Garcia-Godoy F., Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent 2004; 28: 47-52. https://doi.org/10.17796/jcpd.28.1.yg6m443046k50u20</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Turner R.J., Sugiya H. Understanding salivary fluid and protein secretion. Oral Dis 2002; 8: 3-11. https://doi.org/10.1034/j.1601-0825.2002.10815.x</mixed-citation><mixed-citation xml:lang="en">Turner R.J., Sugiya H. Understanding salivary fluid and protein secretion. Oral Dis 2002; 8: 3-11. https://doi.org/10.1034/j.1601-0825.2002.10815.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
