Features of metabolic disorders in chromium mine workers

Introduction. Working conditions, clinical and laboratory status of 236 workers of a chromium mine were investigated. 

Materials and methods. The observation group included 162 underground employees working in conditions of the combined impact of negative occupational factors (dust, noise, vibration, tension and severity there, cooling microclimate) — class 3.3-3.4. The comparison group included 74 mine employees working in acceptable working conditions — class 2. 

Results. In the observation group, the pathology of the cardiovascular and endocrine system (ICD-10: I00-I99, E00-E07) was detected 2.8-3.3 times more often (p = 0.001-0.02), the relative risk of disease formation was 2.7-3.2 times higher than in the comparison group (RR = 2.7-3.2; DI = 1.44-9.2; p = 0.001-0.02). Under the conditions of the combined effect of negative production factors, as features of metabolic disorders, it was noted that the most unfavourable — abdominal form of obesity was diagnosed 1.4 times more often (42.0%, p = 0.013), the atherogenic index was 1.2 times higher, and the level HDL is 1.2 times lower than in the comparison group (p = 0.017-0.047); “Metabolic indices” — lipid accumulation coefficient (LAP) and visceral obesity index (VAI) were 1.2-1.4 times higher than the values ​​in the comparison group (p = 0.001-0.048). 

Conclusions. To implement a complex of medical and preventive measures aimed at increasing life expectancy and working longevity, early prevention of CVD, including among those working in the extraction of chrome ore, it is advisable to consider the introduction of the calculation of early markers of metabolic disorders — VAI and LAP indices in the medical examination programs.

Contribution:

Zaitseva N.V. — concept and design of the study, editing;

Kostarev V.G. — concept and design of the study;

Luzhetskiy K.P. — concept and design of the study, writing a text;

Nosov A.E. — collection and processing of material;

Chigvintsev V.M. — statistical processing;

Ustinova O.Yu. — editing.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: July 8, 2021 / Accepted: September 28, 2021 / Published: October 31, 2021

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