Assessment of violations of critical organs and systems in children with a high content of chromium in the blood

Introduction. Chromium (VI) is a common component of emissions from woodworking enterprises and an extremely dangerous polytropic toxic chemical substance that has a sensitizing, mutagenic and carcinogenic effect. 

The aim of the study was to assess disorders of critical organs and systems in children with an increased chromium content in the blood. 

Materials and methods. The content of chromium in the blood was investigated, the values ​​of clinical and biochemical parameters were estimated, the statistical processing of the data was carried out using the Statistica 10 software. 

Results. The level of chromium in the blood of children from the observation group was 2.4 times higher than in the control group. In children with an increased concentration of chromium in the blood, compared with children in the control group, a significant increase in IgE of total, eosinophilic-lymphocytic index, total and direct bilirubin, low-density lipoprotein, α-amylase and LDH was found to be higher by 1.2-3.1 times. TSH, and a 1.2-fold lowering of HDL cholesterol. Significant relationships were obtained between an increased concentration of chromium in the blood and an increased level of IgE total, eosinophilic-lymphocytic index, α-amylase and TSH (R² = 0.20-0.31, p <0.05), lowered HDL cholesterol (R² = 0.89; p <0.05). The dependence of the frequency of occurrence of allergic rhinitis, cardiomyopathy and diseases of the biliary tract (R² = 0.20-0.96; p <0.05) on the increased level of chromium in the blood was established. 

Conclusion. It is advisable to use the obtained biomarkers of adverse effects to increase the efficiency and form medical and prophylactic programs to reduce the level of chromium in the blood and prevent the negative consequences of its impact on the population.

Contribution:

Perezhogin A.N. — the research concept and design, collection literature, writing the text;

Zemlyanova M.A. — the research concept and design, editing;

Koldibekova Yu.V. — the concept and design of the study, statistical processing of the material, writing the text;

Pustovalova O.V. — collection and processing of material. 

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: July 8, 2021 / Accepted: September 28, 2021 / Published: October 31, 2021

1. Kostyleva L.N. Current state of atmospheric air in large industrial cities. Nauchnyy al’manakh. 2020; 69(7-1): 165–7. (in Russian)

2. Maklakova O.A. Assessing risks of respiratory organs diseases and co-morbid pathology in children caused by ambient air contamination with technogenic chemicals (cohort study). Analiz riska zdorov’yu. 2019; (2): 56–63. https://doi.org/10.21668/health.risk/2019.2.06 (in Russian)

3. Ministry of Natural Resources and Ecology of the Irkutsk Region. State report «On the state and protection of the environment of the Irkutsk region in 2019». Irkutsk: Megaprint; 2020. (in Russian)

4. Barceloux D.G. Chromium. J. Toxicol. Clin. Toxicol. 1999; 37(2): 173–94. https://doi.org/10.1081/clt-100102418

5. WHO. Air Quality Guidelines. Second Edition Chapter 6.4: Chromium. Copenhagen, Denmark: Regional Office for Europe; 2000.

6. Achmad R., Budiawan R., Auerkari E. Effects of chromium on human body. Ann. Res. Rev. Biol. 2017; 13(2): 1–8.

7. Onishchenko G.G., Zaytseva N.V., Zemlyanova M.A. Identification of Health Effects Caused by Environmental Chemical Exposure [Gigienicheskaya indikatsiya posledstviy dlya zdorov’ya pri vneshnesredovoy ekspozitsii khimicheskikh faktorov]. Perm’: Knizhnyy format; 2011. (in Russian)

8. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for Chromium. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service; 2012.

9. Ozgur K., Banu A., Unachukwu M. Mechanism and health effects of heavy metal toxicity in humans. In: Poisoning in the Modern World - New Tricks for an Old Dog? 2019; 1–23. Available at: https://www.intechopen.com/books/poisoning-in-the-modern-world-new-tricks-for-an-old-dog-/mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans https://doi.org/10.5772/intechopen.82511

10. Tietz N.W. Clinical Guide to Laboratory Tests. Philadelphia: W.B. Saunders; 1983.

11. Glantz S.A. Primer of Biostatistics. New-York: McGraw-Hill; 1994.

12. Avtsyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Human Microelementosis. Etiology, Classification, Organopathology [Mikroelementozy cheloveka. Etiologiya, klassifikatsiya, organopatologiya]. Moscow: Meditsina; 1991. (in Russian)

13. Gil F., Hernández A.F., Márquez C., Femia P., Olmedo P., López-Guarnido O., et al. Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. Sci. Total. Environ. 2011; 409(6): 1172–80. https://doi.org/10.1016/j.scitotenv.2010.11.033

14. Petersen R. Half life of chromium in serum and urine in a former plasma cutter of stainless steel. Occup. Environ. Med. 2000; 57(2): 140–2. https://doi.org/10.1136/oem.57.2.140

15. Mamyrbaev A.A. Toxicology of Chromium and its Compounds [Toksikologiya khroma i ego soedineniya]. Aktobe; 2012. (in Russian)

16. Khanturina G.R. Accumulation of chromium salt in the organs of rats at the acute poisoning. Uspekhi sovremennogo estestvoznaniya. 2014; (9): 64–7. (in Russian)

17. Paustenbach D., Finley B., Mowat F., Kerger B. Human health risk and exposure assessment of chromium (VI) in tap water. J. Toxicol. Environ. Health A. 2003; 66(14): 1295–339. https://doi.org/10.1080/15287390306388

18. Baruthio F. Toxic effects of chromium and its compounds. Biol. Trace. Elem. Res. 1992; 32(1-3): 145–53. https://doi.org/10.1007/bf02784599

19. Vozgoment O.V., Ustinova O.Yu., Aminova A.I., Akatova A.A., Belyaeva E.S., Perlova Yu.A. Ultrasound diagnostics of the specificities of dysfunctional disorders of the biliary tract in children chronically exposed to chromium, nickel and chloroform. Fundamental’nye issledovaniya. 2013; (3): 46–52. (in Russian)

20. Mahmood T., Qureshi I.Z., Iqbal M.J. Histopathological and biochemical changes in rat thyroid following acute exposure to hexavalent chromium. Histol. Histopathol. 2010; 25(11): 1355–70. https://doi.org/10.14670/hh-25.1355

21. Qureshi I.Z., Mahmood T. Prospective role of ascorbic acid (vitamin C) in attenuating hexavalent chromium induced functional and cellular damage in rat thyroid. Toxicol. Ind. Health. 2010; 26(6): 349–59. https://doi.org/10.1177/0748233710371109

22. Rana S.V.S. Perspectives in endocrine toxicity of heavy metals – a review. Biol. Trace Elem. Res. 2014; 160(1): 1–14. https://doi.org/10.1007/s12011-014-0023-7