Genetic risk factors for the development of vibration disease (literature review)

Vibration disease (VD) occupies one of the leading places in occupational pathology. This disease is characterized by the complexity of pathogenetic mechanisms, polysyndromicity, chronic course, resistance to therapy, and often leads to disability and disablement in patients. Among the possible risk factors for the development of VD, the attention of researchers is paid to genetic predisposition. The work summarizes the results of modern research on the identification of candidate genes and their polymorphisms that determine predisposition to the occurrence of VD and a number of other diseases that have similar pathogenetic mechanisms. The literature search was carried out in the English text databases PubMed, Scopus, Web of Science and in the scientific electronic library eLIBRARY.ru (RSCI). The review examines polymorphisms of some genes of phase I of xenobiotic detoxification, a family of cation channels with transient receptor potential, superoxide dismutases, glutathione peroxidases, epoxide hydrolases, matrix metalloproteinases, caspases, endothelial nitric oxide synthase, heat shock proteins, folate cycle, sirtuins, endothelins, angiotensin-converting enzyme, serotonin receptor genes, as well as interleukins and tumor necrosis factor genes. Based on literature data, a complex mechanism of interaction between different genes can be assumed to be involved in the formation and development of VD. The results of molecular genetic studies confirm the pathogenetic complexity and polymorphism of the symptoms of VD. Further search and study of new genetic predictors of VD development is required. The data obtained will not only expand our understanding of the pathogenesis and mechanisms of VD development, but also provide tools for prediction and a personalized approach to prevention and treatment.

Contribution:
Muhammadiyeva G.F. – the concept and design of the study, collection and processing of material, writing text, editing;
Shaihlislamova E.R. – the concept and design of the study, editing;
Karimov D.D. – collection and processing of material;
Karimov D.O. – the concept and design of the study, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgment. The work was carried out within the framework of the industry research program of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare for 2021–2025. «Scientific justification for the national system for ensuring sanitary and epidemiological well-being, managing health risks and improving the quality of life of the Russian population» clause 2.2.9.

Received: August 15, 2024 / Accepted: December 3, 2024 / Published: March 31, 2025

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