Angiodystonic syndrome in different stages of the effects of vibration

Introduction. The problem of vibration exposure remains relevant in modern occupational pathology. Modern epidemiological studies show exposure to vibration to be associated with peripheral circulatory disorders, arteriole spasm and the subsequent development of dystrophic changes in the vascular wall.

The purpose of the study. To identify the features of the trend in the pulsation index (PI) of the upper extremities in stages 1 and 2 of effects of vibration from exposure to whole-body and hand-arm vibration by ultrasound.

Materials and methods. Ultrasound scanning of the arteries of the upper extremities was performed in sixty seven patients. In contrast to effects of vibration, the inverse ratio of the total growth rate has been established to be observed from whole-body and hand-arm vibrations only from the whole-body vibration, that is, a higher growth rate occurs at stage 2 of effects of vibration was measured on the distal part of the forearm.

Results. However, at the same time, changes from whole-body and hand-arm vibration are more pronounced in effects of vibration stage 1.

Limitations. The main disadvantages of ultrasound are the long-term and operator-dependent method.

Conclusion. With an increase in the degree of effects of vibration, regardless of the effects of such harmful production factors as whole-body and hand-arm and only whole-body vibration, the difference in changes in the PI index decreases, which is significantly pronounced at the 1^st stages of the disease. Standardization of the protocol of ultrasound examination of the upper extremities will subsequently help to assess the dynamics and level of initial angiodystonic lesions in patients whose diagnosis can prevent irreversible consequences of chronic ischemia at the early stages of development.

Compliance with ethical standards. The study was conducted in compliance with the ethical standards of the Helsinki Declaration of the World Medical Association. The minutes of the meeting of the Local Ethics Committee of the Northwestern Scientific Center for Hygiene and Public Health No. 2022/50.2 dated 12/28/2022 were received. All participants gave informed voluntary written consent to participate in the study.

Contribution:
Kuprina N.I. — the concept and design of the study, collection and processing of material, statistical processing, writing a text, editing;
Petrova M.D. — processing of material, writing a text;
Shilov V.V. — responsibility for the integrity of all parts of the manuscript and approval of the manuscript final version;
Kovshov A.A. – statistical processing, analysis and interpretation of results, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: April 25, 2025 / Revised: July 14, 2025 / Accepted: July 22, 2025 / Published: September 25, 2025

1. Krajnak K. Health effects associated with occupational exposure to hand-arm or whole-body vibration. J. Toxicol. Environ. Health B. Crit. Rev. 2018; 21(5): 320–34. https://doi.org/10.1080/10937404.2018.1557576

2. AlShabi M., Araydah W., Elshatarat H., Othman M., Bani Younis M., Gadsden S. Effect of mechanical vibrations on human body. World J. Mech. 2016; 6(9): 273–304. https://doi.org/10.4236/wjm.2016.69022

3. Gerhardsson L., Ahlstrand C., Ersson P., Gustafsson E. Vibration-induced injuries in workers exposed to transient and high-frequency vibrations. J. Occup. Med. Toxicol. 2020; 15: 18. https://doi.org/10.1186/s12995-020-00269-w

4. Tekavec E., Nilsson T., Dahlin L.B., Huynh E., Axmon A., Nordander C., et al. Serum biomarkers in patients with hand-arm vibration injury and in controls. Sci. Rep. 2024; 14(1): 2719. https://doi.org/10.1038/s41598-024-52782-1

5. Vihlborg P., Makdoumi K., Gavlovská H., Wikström S., Graff P. Arterial abnormalities in the hands of workers with vibration white fingers. J. Occup. Med. Toxicol. 2021; 16(1): 30. https://doi.org/10.1186/s12995-021-00323-1

6. Piňosová M., Andrejiova M. Application of data-mining methods in the assessment of excessive vibrations: decision trees, basket-market analysis. Acta Mechanica Slovaca. 2024; 28(3): 60–73. https://doi.org/10.21496/ams.2025.002

7. Babanov S.A., Baraeva R.A., Strizhakov L.A., Moiseev S.V., Fomin V.V. The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension. Terapevticheskii arkhiv. 2021; 93(6): 693–8. https://doi.org/10.26442/00403660.2021.06.200880 https://elibrary.ru/kzwgfk (in Russian)

8. Nilsson T., Wahlström J., Burström L. Hand-arm vibration and the risk of vascular and neurological diseases – a systematic review and meta-analysis. PLoS One. 2017; 12(7): e0180795. https://doi.org/10.1371/journal.pone.0180795

9. Krajnak K., Waugh S. Systemic effects of segmental vibration in an animal model of hand-arm vibration syndrome. J. Occup. Environ. Med. 2018; 60(10): 886–95. https://doi.org/10.1097/jom.0000000000001396

10. Wei N., Yan R., Lang L., Wei Y., Li J., Yang H., et al. Local vibration induced vascular pathological structural changes and abnormal levels of vascular damage indicators. Microvasc. Res. 2021; 136: 104163. https://doi.org/10.1016/j.mvr.2021.104163

11. Alfieri G.R., Eaton A.C., Dourvetakis K., Rigueros M., Creamean T., Mayrovitz H.N. Impact of whole-body vibration therapy in elderly populations: a scoping review. Cureus. 2025; 17(2): e79296. https://doi.org/10.7759/cureus.79296

12. Tretyakov S.V. The state of the cardiovascular system under the influence of vibration (clinical and pathogenetic aspects). Mezhdunarodnyi nauchno-issledovatel’skii zhurnal. 2023; (9). https://doi.org/10.23670/IRJ.2023.135.38 (in Russian)

13. Sukhova A.V., Preobrazhenskaya E.A. Personalized assessment of the risk of hypertension when exposed to noise and vibration. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2024; 103(11): 1304–11. https://doi.org/10.47470/0016-9900-2024-103-11-1304-1311 https://elibrary.ru/ythegc (in Russian)

14. Silva E., Lisboa I.C., Costa N. How to determine hands’ vibration perception thresholds – a systematic review. Behav. Res. Methods. 2024; 57(1): 27. https://doi.org/10.3758/s13428-024-02534-w

15. Gerhardsson L. A follow-up study of vibration-induced injuries in workers exposed to transient and high frequency vibrations. J. Occup. Med. Toxicol. 2024; 19(1): 27. https://doi.org/10.1186/s12995-024-00425-6

16. Loomis K.J., Shin J., Roll S.C. Current and future utility of ultrasound imaging in upper extremity musculoskeletal rehabilitation: A scoping review. J. Hand Ther. 2024; 37(3): 331–47. https://doi.org/10.1016/j.jht.2023.09.014

17. Roll S.C., McLaughlin Gray J., Frank G., Wolkoff M. Exploring occupational therapists’ perceptions of the usefulness of musculoskeletal sonography in upper-extremity rehabilitation. Am. J. Occup. Ther. 2015; 69(4): 6904350020p1-6. https://doi.org/10.5014/ajot.2015.016436

18. Avrahami I., Kersh D., Liberzon A. Pulsatility index as a diagnostic parameter of reciprocating wall shear stress parameters in physiological pulsating waveforms. PLoS One. 2016; 11(11): e0166426. https://doi.org/10.1371/journal.pone.0166426

19. Melentev A.V., Oshkoderov O.A. Assessment of the diagnostic significance of modern biomarkers and hemodynamic alterations in workers of vibration-hazardous occupations. Zdravookhranenie Rossiiskoi Federatsii. 2021; 65(4): 379–83. https://doi.org/10.47470/0044-197X-2021-65-4-379-383 https://elibrary.ru/dmqmus (in Russian)

20. Wahl U., Kaden I., Köhler A., Hirsch T. Vascular trauma of the hand – a systematic review. Vasa. 2019; 48(3): 205–15. https://doi.org/10.1024/0301-1526/a000743

21. Tekavec E., Nilsson T., Dahlin L.B., Axmon A., Nordander C., Riddar J., et al. Biomarkers in patients with hand-arm vibration injury entailing Raynaud’s phenomenon and cold sensitivity, compared to referents. Proceedings. 2023; 86(1): 27. https://doi.org/10.3390/proceedings2023086027

22. Marcoccia A., Klein-Weigel P., Gschwandtner M., Wautrecht J.-C., Matuska J., Rother U., et al. Microcirculatory assessment of vascular diseases. Vasa. 2020; 49(3): 175–86. https://doi.org/10.1024/0301-1526/a000851

23. Golemati S., Cokkinos D.D. Recent advances in vascular ultrasound imaging technology and their clinical implications. Ultrasonics. 2022; 119: 106599. https://doi.org/10.1016/j.ultras.2021.106599