Micro- and nanoplastics: origin, sources of intake and impact on human health (literature review)

This review aims to consolidate information on the mechanisms of interaction between microplastics and living organisms and analyze the impact of these processes on health. For this review, relevant scientific reports were found through an online search in the bibliographic resources Scopus, Web of Science, and Google Scholar.

Accumulated scientific research convincingly demonstrates micro- and nanoplastics to represent an increasingly serious problem for the environment and human health, requiring a comprehensive and multifaceted consideration. Their widespread occurrence in natural systems and the human body and their unique physicochemical properties, distinguish them as an emerging pollutant that can have a significant adverse impact on various organs and systems, including the endocrine, nervous, respiratory, cardiovascular, and reproductive systems. Despite the progress made in their study, significant gaps in understanding remain, especially with regard to the mechanisms of toxic effects, the effects of long-term exposure and interactions with other chemical compounds.

Conclusion. There is a need to intensify scientific research, develop better detection methods and implement effective strategies to reduce adverse impacts at both local and global levels. There is also emphasized the need to develop effective public policies, update regulations, improve environmental awareness and revise consumption patterns, which will reduce plastic production and promote the development of a circular economy. Only through concerted action by governments, industry, the scientific community, and citizens will it be possible to effectively address this problem, ensuring the protection of human health and the preservation of the planet.

Contribution:
Lukin A.A. — writing the article;
Gazeev I.R. — review concept;
Gizatova N.V. — compiling a summary, literary processing;
Latypova G.F. — data processing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: July 7, 2025 / Accepted: October 15, 2025 / Published: November 14, 2025

1. Akanyange S.N., Lyu X., Zhao X., Li X., Zhang Y., Crittenden J.C., et al. Does microplastic really represent a threat? A review of the atmospheric contamination sources and potential impacts. Sci. Total. Environ. 2021; 777: 146020. https://doi.org/10.1016/j.scitotenv.2021.146020

2. Shen M., Zeng Z., Song B., Yi H., Hu T., Zhang Y., et al. Neglected microplastics pollution in global COVID-19: Disposable surgical masks. Sci. Total. Environ. 2021; 790: 148130. https://doi.org/10.1016/j.scitotenv.2021.148130

3. Lehner R., Weder C., Petri-Fink A., Rothen-Rutishauser B. Emergence of nanoplastic in the environment and possible impact on human health. Environ. Sci. Technol. 2019; 53(4): 1748–65. https://doi.org/10.1021/acs.est.8b05512

4. Castañeta G., Gutiérrez A.F., Nacaratte F., Manzano C.A. Microplásticos: un contaminante que crece en todas las esferas ambientales, sus características y posibles riesgos para la salud pública por exposición. Rev. Boliv. Quím. 2020; 37(3): 160–75. https://doi.org/10.34098/2078-3949.37.3.4

5. Kim Y., Jeong J., Lee S., Choi I., Choi J. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. J. Hazard. Mater. 2020; 388: 121725. https://doi.org/10.1016/j.jhazmat.2019.121725

6. Zhu L., Zhu J., Zuo R., Xu Q., Qian Y., An L. Identification of microplastics in human placenta using laser direct infrared spectroscopy. Sci. Total. Environ. 2023; 856(Pt. 1): 159060. https://doi.org/10.1016/j.scitotenv.2022.159060

7. Flaws J., Damdimopoulou P., Patisaul H.B., Gore A., Raetzman L., Vandenberg L.N. Plastics, EDCs & Health: a guide for public interest organizations and policy-makers on endocrine disrupting chemicals & plastics. Endocrine Society and IPEN; 2020.

8. Bayo J., Baeza-Martínez C., González-Pleiter M., García-Pachón E., López-Castellanos J., Doval M., et al. Respiramos plástico: detección de microplásticos en el sistema respiratorio humano. Rev. Salud. Ambient. 2024; 24(1): 107–16.

9. Zheng H., Vidili G., Casu G., Navarese E.P., Sechi L.A., Chen Y. Microplastics and nanoplastics in cardiovascular disease – a narrative review with worrying links. Front. Toxicol. 2024; 6: 1479292. https://doi.org/10.3389/ftox.2024.1479292

10. Anand U., Dey S., Bontempi E., Ducoli S., Vethaak A.D., Dey A., et al. Biotechnological methods to remove microplastics: a review. Environ. Chem. Lett. 2023; 21(3): 1787–810. https://doi.org/10.1007/s10311-022-01552-4

11. Veluru S., Ramakrishna S. Biotechnological approaches: degradation and valorization of waste plastic to promote the circular economy. Circular. Economy. 2024; 3(1): 100077. https://doi.org/10.1016/j.cec.2024.100077

12. Bennett E.R., Panagiotakis I. Microplastic in the Environment: Pattern and Process. Environmental Contamination Remediation and Management. Cham: Springer; 2022. https://doi.org/10.1007/978-3-030-78627-4

13. Song J., Cui S., Li P., Mingrui L. Progress on ecotoxicological effects of microplastics loaded pollutants. IOP Conf. Ser. Earth Environ. Sci. 2018; 186(3): 012027.

14. Burghardt T.E., Pashkevich A., Babić D., Mosböck H., Babić D., Żakowska L. Microplastics and road markings: the role of glass beads and loss estimation. Transp. Res. D. Transp. Environ. 2022; 102: 103123. https://doi.org/10.1016/j.trd.2021.103123

15. Mason S.A., Welch V.G., Neratko J. Synthetic polymer contamination in bottled water. Front. Chem. 2018; 6: 407. https://doi.org/10.3389/fchem.2018.00407

16. Zhou G., Wu Q., Tang P., Chen Ch., Cheng X., Wei X.F., et al. How many microplastics do we ingest when using disposable drink cups? J. Hazard. Mater. 2023; 441: 129982. https://doi.org/10.1016/j.jhazmat.2022.129982 https://elibrary.ru/bscmek

17. Anderson A.G., Grose J., Pahl S., Thompson R.C., Wyles K.J. Microplastics in personal care products: Exploring perceptions of environmentalists, beauticians and students. Mar. Pollut. Bull. 2016; 113(1–2): 454–60. https://doi.org/10.1016/j.marpolbul.2016.10.048

18. De Falco F., Di Pace E., Cocca M., Avella M. The contribution of washing processes of synthetic clothes to microplastic pollution. Sci. Rep. 2019; 9(1): 6633. https://doi.org/10.1038/s41598-019-43023-x

19. Hussain K.A., Romanova S., Okur I., Zhang D., Kuebler J., Huang X., et al. Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health. Environ. Sci. Technol. 2023; 57(26): 9782–92. https://doi.org/10.1021/acs.est.3c01942

20. Yin J., Ju Y., Qian H., Wang J., Miao X., Zhu Y., et al. Nanoplastics and microplastics may be damaging our livers. Toxics. 2022; 10(10): 586. https://doi.org/10.3390/toxics10100586

21. Molina E., Benedé S. Is there evidence of health risks from exposure to micro- and nanoplastics in foods? Front. Nutr. 2022; 9: 910094. https://doi.org/10.3389/fnut.2022.910094

22. Schwarzfischer M., Rogler G. The intestinal barrier – shielding the body from nano- and microparticles in our diet. Metabolites. 2022; 12(3): 223. https://doi.org/10.3390/metabo12030223

23. Zhao B., Rehati P., Yang Z., Cai Z., Guo C., Li Y. The potential toxicity of microplastics on human health. Sci. Total. Environ. 2024; 912: 168946. https://doi.org/10.1016/j.scitotenv.2023.168946

24. Ali N., Katsouli J., Marczylo E.L., Gant T.W., Wright S., Bernardino de la Serna J. The potential impacts of micro-and-nano plastics on various organ systems in humans. EBioMedicine. 2024; 99: 104901. https://doi.org/10.1016/j.ebiom.2023.104901

25. Blackburn K., Green D. The potential effects of microplastics on human health: What is known and what is unknown. Ambio. 2022; 51(3): 518–30. https://doi.org/10.1007/s13280-021-01589-9

26. Zhang D., Wu C., Liu Y., Li W., Li S., Peng L., et al. Microplastics are detected in human gallstones and have the ability to form large cholesterol-microplastic heteroaggregates. J. Hazard. Mater. 2024; 467: 133631. https://doi.org/10.1016/j.jhazmat.2024.133631

27. Martin-Folgar R., González-Caballero M.C., Torres-Ruiz M., Cañas-Portilla A.I., de Alba González M., Liste I., et al. Molecular effects of polystyrene nanoplastics on human neural stem cells. PLoS One. 2024; 19(1): e0295816. https://doi.org/10.1371/journal.pone.0295816

28. Bonanomi M., Salmistraro N., Porro D., Pinsino A., Colangelo A.M., Gaglio D. Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health. Chemosphere. 2022; 303(Pt. 1): 134947. https://doi.org/10.1016/j.chemosphere.2022.134947

29. Chen Z., Li Y., Xia H., Wang Y., Pang S., Ma C., et al. Chronic exposure to polystyrene microplastics increased the chemosensitivity of normal human liver cells via ABC transporter inhibition. Sci. Total. Environ. 2024; 912: 169050. https://doi.org/10.1016/j.scitotenv.2023.169050