Deviation of laboratory blood parameters from reference limits in workers under the conditions of the Far North

Introduction. Blood indicators reflect the influence of conditions in the Far North on the body of workers.

Goal. The assessment of disadaptation in workers in the Far North based on deviations of laboratory blood parameters from reference limits.

Materials and methods. The results of blood tests in male military personnel of three groups (nn=12, 10, 15) were analyzed. The presence and severity (in %) of deviations from the reference limits were ranked in points for the indicators of lipids, C-reactive protein, vitamins (B₉, B₁₂, D), minerals (ionized and total calcium, potassium, sodium, magnesium, phosphorus, iron). An individual’s maladaptation was determined by the sum of points, severity, and indicators; group 2 by average, severity in general, indicators and proportion with the severity of deviations.

Results. Work experience was 2.5±0.15; 5.2±0.15 (p1–2=0.001) and 7.1±0.2 years (p1–3=0.001; p2–3=0.001). Individual in group No. 1 had deviations from the norm of 7 points, the severity of disadaptation was 29.2%. In the group 5.5±0.4 points, deviations in 100.0%, severity 22.9%. Working group No. 2 has a total score of 7, the severity of disadaptation is 29.2%. In the group, the sum was 8.9±0.7 points (p1–2=0.001), deviations in 100.0%, severity 37.1%. In group No. 3, the examined person had a total score of 11, severity of 45.8%. For the group – 11.0±0.5 (p1–3=0.001; p2–3=0.022) points; disadaptation in 100.0%, severity 45.8%. An increase in the severity of disadaptation with an increase in work experience by 7.9-16.6%.

Limitations. Blood parameters in male military personnel, differing in duration of work in the Far North.

Conclusion. The increase in disadaptation in an individual, by group, by indicators depending on work experience, proves the extreme influence of the North on health. The method made it possible to recommend prevention: group No. 1 – correction of dyslipidemia and hypovitaminosis; No. 2 – additionally higher doses of vitamin D, calcium, correction of inflammation; No. 3 – additionally mineral deficiency.

Compliance with ethical standards. The work was carried out in accordance with the conclusion of the Ethics Committee of the Volga Research Medical University of the Ministry of Health of Russia, protocol No. 4 dated March 14, 2022.

Patient consent. Each participant of the study (or his/her legal representative) gave informed voluntary written consent to participate in the study and publish personal medical information in an impersonal form in the journal “Gigiena i Sanitariya (Hygiene and Sanitation, Russian journal)”.

Conribution:
Rakhmanov R.S. – concept and design of the study, writing the text, responsibility for the integrity of all parts of the article;
Bogomolova E.S. – editing, approval of the final version of the article;
Razgulin S.A. – participation in the interpretation of results, preparation of the text;
Narutdinov D.A. – collection and systematization of primary material;
Potekhina N.N. – statistical processing of the material;
Alikberov M.Kh. – collection of literature data.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship. The work was carried out according to the scientific work plan of the Federal State Budgetary Educational Institution of Higher Medical Education "PIMU" of the Ministry of Health of the Russian Federation and according to the dissertation research plan of D.A. Narutdinov.

Received: June 6, 2024 / Revised: October 23, 2024 / Accepted: Dececmber 3, 2024 / Published: March 31, 2025

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