Informative indices for risk groups working in contact with hand-arm vibration

Introduction. The nature of occupational and work-related pathology and its clinical course are determined not only by the intensity of exposure to factors in the work environment, but also by the individual characteristics.

The purpose of the study is to assess the contribution of occupational factors and individual characteristics of workers and substantiate the most significant informative indices for forming risk groups for the development of vibration disease caused by exposure to local vibration.

Materials and methods. The studies were conducted on the basis of an information array of indices in practically healthy workers exposed to vibration and people with hand-arm vibration syndrome (HAVS). The principal component method with varimax rotation was used to identify factors and their structure. Logistic regression analysis was used to determine the influence of bioelectrical activity of the brain, the state of the endocrine system, and the psychological parameters on the probability of HAVS formation; ROC analysis to check the quality of the model was applied.

Results. Five main principal components, which together explain 62.79% and 69.84% of the variance, were identified in the group of practically healthy individuals and HAVS individuals, respectively. Emotional and personal variables dominate in the factor matrices of individuals in both groups; one-way direction of the structural unification of variables into factors is observed. A combination of factors with the maximum percentage of correctly predicted cases (93.8%) was established; the model has high sensitivity (94.9%) and specificity (92.1%). The most informative parameter is the experienced vibration dose, then in descending order – the indicators of the 1^st and 2^nd MMPI scales, interhemispheric asymmetry in amplitude in the T3–T4 lead of the theta rhythm, Fp1–Fp2 of the delta rhythm, the integral pituitary-adrenal index.

Limitations. The study was conducted without taking into account biochemical and immunological indices.

Conclusion. The basis of the complex of psychological manifestations in workers exposed to hand-arm vibration is formed by two factors that determine the general trends in the formation of the psycho-emotional state. The simultaneous combination of variables – the vibration exposure dose, the state of the functional activity of the brain, the endocrine system, and the psycho-emotional state, should be considered as risk factors for the formation of HAVS.

Compliance with ethical standards. The study was performed in accordance with ethical standards and approved by the Local Ethics Committee of the East-Siberian Institute of Medical and Ecological Research (conclusion No. 6 dated November 15, 2012, conclusion No. 2 dated December 21, 2017). All participants gave informed voluntary written consent to participate in the study.

Contribution:
Kuleshova M.V. – concept and design of the study, collection and processing of material, statistical processing, writing text, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Pankov V.A. – concept of the study, collection of material, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version

Conflict of interest. The authors declare no conflict of interest.

Funding. The work was performed within the funds allocated for the implementation of the State task for the East-Siberian Institute of Medical and Ecological Research.

Received: July 3, 2025 / Accepted: September 19, 2025 / Published: October 20, 2025

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