The association between cognitive impairments in patients with vibration disease with the content of cytokines, neurotrophins, and antibodies to nervous tissue proteins

Introduction. In the era of the modern technological industry, the study of the pathogenesis of occupational diseases of the nervous system is of great medical and social importance. At the same time, the social and occupational adaptation in patients determines, among other things, the state of the cognitive sphere. To date, the regulatory relationships between cytokines, antibodies (AB) to nerve tissue proteins and neurotrophins, which will allow tracing pathological failures in the psycho-emotional sphere in patients with vibration disease (VD), depending on the presence or absence of cognitive impairments (CI), have not been sufficiently studied.

Materials and methods. Serum cytokine (IL-1β, IL-4, IL-6, IL-8, TNF-α) concentrations were analyzed by enzyme-linked immune sorbent assay; dopamine, BDNF, CNTF. Determination of IgG class AB directed to nerve tissue proteins: S-100, GFAP, MBM, NF-200, V-dep. Ca-channel, ACh-R, Glu-R, GABA-R, DA-R, Ser-R, M-OR, B-end.

Results. In VD patients, regardless of the presence or absence of cognitive disorders, there is a proinflammatory tendency of changes in the cytokine profile (IL-1β, IL-6, IL-8), an increase in dopamine, BDNF and CNTF levels, in the production of neuronal ABs to nerve tissue proteins (S-100, MBM, NF-200, V-dep. Ca-channel, ACh-R, Glu-R, GABA-R, DA-R, Ser-R, M-OR, B-end). At the same time, differences in regulatory relationships between cytokines, neuronal Abs, and neurotrophins have been established in patients with and without VD and CI.

Limitations. Small groups of patients.

Conclusion. Impaired cytokine regulation of the neuroautoimmune response may indicate a more pronounced neuroimmunoinflammatory response in patients suffered from VD burdened with CI.

Compliance with ethical standards. During the study were observed the ethical standards of the Helsinki Declaration of the World Medical Association “Ethical Principles for Conducting Scientific Medical Research with Human Participation” (2024), with the signing of informed consent to participate in the study. There is a conclusion of the Local Ethics Committee of the FSBSI ESIMER (protocol No. 5 dated 21.03.2023).

Contribution:
Naumova O.V. — collection and processing of material, writing of text, editing;
Bodienkova G.M. — concept and design of research, collection and processing of material, writing of text, editing;
Boklazhenko E.V. — collection and processing of material, statistical processing, writing of text;
Shevchenko O.I. — collection and processing of material, statistical processing, writing of text;
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Funding. The work was performed within the framework of funds allocated for the implementation of the state task East-Siberian Institute of Medical and Ecological Research.

Received: June 5, 2025 / Accepted: October 15, 2025 / Published: November 14, 2025

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