Paracetamol hepatotoxicity against the background of chronic stress: morphology and antioxidant gene activity in rats

Alina A. Gizatullina; Denis O. Karimov; Tatyana G. Yakupova; Yulia V. Ryabova; Yana V. Valova; Eldar R. Kudoyarov; Denis A. Smolyankin; Nadezhda Yu. Khusnutdinova; Алина Анваровна Гизатуллина; Денис Олегович Каримов; Татьяна Георгиевна Якупова; Юлия Владимировна Рябова; Яна Валерьевна Валова; Эльдар Ренатович Кудояров; Денис Анатольевич Смолянкин; Надежда Юрьевна Хуснутдинова

Hygiene and Sanitation
Gigiena i sanitariya

ISSN 0016-9900 (Print)
ISSN 2412-0650 (Online)

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Gizatullina A.A., Karimov D.O., Yakupova T.G., Ryabova Yu.V., Valova Ya.V., Kudoyarov E.R., Smolyankin D.A., Khusnutdinova N.Yu. Paracetamol hepatotoxicity against the background of chronic stress: morphology and antioxidant gene activity in rats. Hygiene and Sanitation. 2025;104(5):655-662. (In Russ.) https://doi.org/10.47470/0016-9900-2025-104-5-655-662. EDN: eqatnx

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ISSN 0016-9900 (Print)
ISSN 2412-0650 (Online)

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About the Authors

Alina A. Gizatullina
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

Junior Researcher at the Department of Toxicology and Genetics with an Experimental Clinic for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: alinagisa@yandex.ru

Denis O. Karimov
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»; ФГБУН «Национальный научно-исследовательский институт общественного здоровья имени Н.А. Семашко»
Russian Federation

PhD (Medicine), Head of the Department of Toxicology and Genetics with an Experimental Clinic for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation, Leading Researcher, Public Health Research Department, N.A. Semashko National Research Institute of Public Health, Moscow, 105064, Russian Federation

e-mail: karimovdo@gmail.com

Tatyana G. Yakupova
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

Junior Researcher at the Genetics Laboratory, Department of Toxicology and Genetics with an Experimental Clinic for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: tanya.kutlina.92@mail.ru

Yulia V. Ryabova
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

PhD (Medicine), Head of the Toxicology Laboratory, Department of Toxicology and Genetics with an Experimental Clinic for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: ryabovaiuvl@gmail.com

Yana V. Valova
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

PhD (Biology), Head of the Genetics Laboratory, Department of Toxicology and Genetics with an Experimental Clinic for Laboratory Animals, Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation

e-mail: Q.juk@yandex.ru

Eldar R. Kudoyarov
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

e-mail: ekudoyarov@gmail.com

Denis A. Smolyankin
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

Junior Researcher, Toxicology Laboratory, Department of Toxicology and Genetics with Experimental Clinic of Laboratory Animals, Ufa Research Institute of Occupational Medicine and Human Ecology, Ufa, 450106, Russian Federation

e-mail: smolyankin.denis@yandex.ru

Nadezhda Yu. Khusnutdinova
ФБУН «Уфимский научно-исследовательский институт медицины труда и экологии человека»
Russian Federation

Researcher of the Toxicology laboratory of the toxicology and genetics department with the experimental clinic of laboratory animals of the Ufa Research Institute of Occupational Medicine and Human Ecology, Ufa, 450106, Russian Federation

e-mail: h-n-yu@yandex.ru

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